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CATSPER1 elisa kit :: Canine Cation channel sperm-associated protein 1 (CATSPER1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7227858 CATSPER1 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cation channel sperm-associated protein 1 (CATSPER1), ELISA Kit

 Also Known As   

Canine Cation channel sperm-associated protein 1 (CATSPER1) ELISA Kit

 Product Gene Name   

CATSPER1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 612997
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 Species Reactivity    Canine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CATSPER1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CATSPER1 purchase    MBS7227858 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cation channel sperm-associated protein 1 (CATSPER1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CATSPER1. The ELISA analytical biochemical technique of the MBS7227858 kit is based on CATSPER1 antibody-CATSPER1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CATSPER1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CATSPER1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for CATSPER1 elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for CATSPER1. It may not necessarily be applicable to this product.
 NCBI GI #    221316609
 NCBI GeneID    117144
 NCBI Accession #    NP_444282.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_053054.3 [Other Products]
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 UniProt Secondary Accession #    Q96P76 [Other Products]
 UniProt Related Accession #    Q8NEC5 [Other Products]
 Molecular Weight    90,091 Da
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 NCBI Official Full Name    cation channel sperm-associated protein 1
 NCBI Official Synonym Full Names    cation channel, sperm associated 1
 NCBI Official Symbol    CATSPER1 [Similar Products]
 NCBI Official Synonym Symbols   
SPGF7; CATSPER
[Similar Products]
 NCBI Protein Information    cation channel sperm-associated protein 1; hCatSper; sperm ion channel; sperm-associated cation channel 1
 UniProt Protein Name    Cation channel sperm-associated protein 1
 Protein Family    Cation channel sperm-associated protein
 UniProt Gene Name    CATSPER1 [Similar Products]
 UniProt Synonym Gene Names    CatSper1; hCatSper [Similar Products]
 UniProt Entry Name    CTSR1_HUMAN
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 NCBI Summary for CATSPER1    Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CATSPER1    CATSPER1: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Defects in CATSPER1 are the cause of spermatogenic failure type 7 (SPGF7). An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: plasma membrane

Molecular Function: voltage-gated calcium channel activity; protein binding; calcium activated cation channel activity

Biological Process: sperm-egg recognition; sperm motility; fusion of sperm to egg plasma membrane; single fertilization; multicellular organismal development; spermatogenesis; regulation of calcium ion transport; cell differentiation; multicellular organism reproduction

Disease: Spermatogenic Failure 7
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 Research Articles on CATSPER1    1. Progesterone via CatSper activates the PI3K-AKT pathway required for motility and hyperactivation but not for acrosome reaction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CATSPER1 elisa kitPathways associated with CATSPER1 elisa kit
 Reference Product  PubMed Publications
 CATSPER2 elisa kit  >22 publications with CATSPER1 and CATSPER2
 CATSPER3 elisa kit  >9 publications with CATSPER1 and CATSPER3
 CATSPER4 elisa kit  >8 publications with CATSPER1 and CATSPER4
 CACNA1I elisa kit  >1 publications with CATSPER1 and CACNA1I
 CATSPERB elisa kit  >1 publications with CATSPER1 and CATSPERB
 CATSPERG elisa kit  >1 publications with CATSPER1 and CATSPERG
 Products by Pathway  Pathway Diagram
 Fertilization Pathway antibodies  Fertilization Pathway Diagram
 Reproduction Pathway antibodies  Reproduction Pathway Diagram
 Sperm Motility And Taxes Pathway antibodies  Sperm Motility And Taxes Pathway Diagram
Diseases associated with CATSPER1 elisa kitOrgans/Tissues associated with CATSPER1 elisa kit
 Disease Name  Pubmed Publications
 Genital Diseases, Male Antibodies  >14 publications with CATSPER1 and Genital Diseases, Male
 Infertility, Female Antibodies  >4 publications with CATSPER1 and Infertility, Female
 Chromosome Aberrations Antibodies  >1 publications with CATSPER1 and Chromosome Aberrations
 Inflammation Antibodies  >1 publications with CATSPER1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >22 publications with CATSPER1 and Testis
 Bone Antibodies  >1 publications with CATSPER1 and Bone
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