NP_001244068.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75,157 Da
NCBI Official Full Name
chloride channel protein ClC-Ka isoform 3
NCBI Official Synonym Full Names
chloride channel, voltage-sensitive Ka
NCBI Protein Information
chloride channel protein ClC-Ka; chloride channel Ka; chloride channel, kidney, A
UniProt Protein Name
Chloride channel protein ClC-Ka
UniProt Synonym Protein Names
ClC-K1
UniProt Synonym Gene Names
UniProt Entry Name
CLCKA_HUMAN
NCBI Summary for CLCNKA
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CLCNKA
CLCNKA: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Defects in CLCNKA are a cause of Bartter syndrome type 4B (BS4B). A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness. Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: metal ion binding; voltage-gated chloride channel activity
Biological Process: transport; excretion; transmembrane transport
Disease: Bartter Syndrome, Type 4b
Research Articles on CLCNKA
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Products associated with CLCNKA elisa kit
Pathways associated with CLCNKA elisa kit
Diseases associated with CLCNKA elisa kit
Organs/Tissues associated with CLCNKA elisa kit
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