NP_963999.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,950 Da
NCBI Official Full Name
chromodomain-helicase-DNA-binding protein 8
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 8
NCBI Official Synonym Symbols
Duplin; HELSNF1; AU015341; mKIAA1564; 5830451P18Rik [Similar Products]
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 8; CHD-8; axis duplication inhibitor; ATP-dependent helicase CHD8; helicase with SNF2 domain 1
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 8
UniProt Synonym Protein Names
ATP-dependent helicase CHD8; Axis duplication inhibitor; Duplin
UniProt Synonym Gene Names
UniProt Entry Name
CHD8_MOUSE
UniProt Comments for CHD8
CHD-8: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1- targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Helicase; Transcription factor; EC 3.6.4.12
Cellular Component: nucleoplasm; protein complex; nucleus
Molecular Function: DNA-dependent ATPase activity; histone binding; hydrolase activity; p53 binding; beta-catenin binding; nucleotide binding; helicase activity; methylated histone residue binding; protein binding; DNA helicase activity; hydrolase activity, acting on acid anhydrides; DNA binding; chromatin binding; ATP binding
Biological Process: negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; transcription, DNA-dependent; in utero embryonic development; positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; DNA duplex unwinding; regulation of transcription, DNA-dependent; gut development; ATP-dependent chromatin remodeling; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
Research Articles on CHD8
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Pathways associated with CHD8 elisa kit
Diseases associated with CHD8 elisa kit
Organs/Tissues associated with CHD8 elisa kit
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