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COL4 elisa kit :: Canine Collagen Type lV ELISA Kit

Scan QR to view Datasheet Catalog #    MBS010428 COL4 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen Type lV (COL4), ELISA Kit

 Also Known As   

Canine Collagen Type lV ELISA Kit

 Product Gene Name   

COL4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    120220
 3D Structure    ModBase 3D Structure for P12109
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 Species Reactivity    Canine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of COL4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for COL4 purchase    MBS010428 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Collagen Type lV (COL4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COL4. The ELISA analytical biochemical technique of the MBS010428 kit is based on COL4 antibody-COL4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COL4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COL4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for COL4. It may not necessarily be applicable to this product.
 NCBI GI #    87196339
 NCBI GeneID    1291
 NCBI Accession #    NP_001839.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001848.2 [Other Products]
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 UniProt Primary Accession #    P12109 [Other Products]
 UniProt Secondary Accession #    O00117; O00118; Q14040; Q14041; Q16258; Q7Z645; Q9BSA8 [Other Products]
 UniProt Related Accession #    P12109 [Other Products]
 Molecular Weight    108,529 Da
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 NCBI Official Full Name    collagen alpha-1(VI) chain
 NCBI Official Synonym Full Names    collagen, type VI, alpha 1
 NCBI Official Symbol    COL6A1 [Similar Products]
 NCBI Official Synonym Symbols   
OPLL
[Similar Products]
 NCBI Protein Information    collagen alpha-1(VI) chain; collagen alpha-1(VI) chain; alpha 1 (VI) chain (61 AA); collagen VI, alpha-1 polypeptide
 UniProt Protein Name    Collagen alpha-1(VI) chain
 Protein Family    Zinc finger protein CONSTANS
 UniProt Gene Name    COL6A1 [Similar Products]
 UniProt Entry Name    CO6A1_HUMAN
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 NCBI Summary for COL4    The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for COL4    COL6A1: Collagen VI acts as a cell-binding protein. Defects in COL6A1 are a cause of Bethlem myopathy (BM). BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles. Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD); also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy. Belongs to the type VI collagen family.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; protein complex; membrane; endoplasmic reticulum lumen; lysosomal membrane; extracellular region; sarcolemma; collagen type VI

Molecular Function: platelet-derived growth factor binding

Biological Process: osteoblast differentiation; axon guidance; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; cell adhesion

Disease: Bethlem Myopathy; Ullrich Congenital Muscular Dystrophy
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 Research Articles on COL4    1. Mutations in each of the three collagen VI genes, COL6A1, COL6A2 and COL6A3, cause four types of muscle disorders: Ullrich congenital muscular dystrophy, Bethlem myopathy, limb-girdle muscular dystrophy, and autosomal recessive myosclerosis. (Review)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with COL4 elisa kitPathways associated with COL4 elisa kit
 Reference Product  PubMed Publications
 COL6A2 elisa kit  >76 publications with COL4 and COL6A2
 COL6A3 elisa kit  >56 publications with COL4 and COL6A3
 COL3A1 elisa kit  >12 publications with COL4 and COL3A1
 COL1A1 elisa kit  >11 publications with COL4 and COL1A1
 COL5A1 elisa kit  >6 publications with COL4 and COL5A1
 COL1A2 elisa kit  >5 publications with COL4 and COL1A2
 COL2A1 elisa kit  >3 publications with COL4 and COL2A1
 COL4A2 elisa kit  >1 publications with COL4 and COL4A2
 COL15A1 elisa kit  >1 publications with COL4 and COL15A1
 ITGA6 elisa kit  >1 publications with COL4 and ITGA6
 Products by Pathway  Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with COL4 elisa kitOrgans/Tissues associated with COL4 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >87 publications with COL4 and Nervous System Diseases
 Bethlem myopathy Antibodies  >60 publications with COL4 and Bethlem myopathy
 Muscular Dystrophies Antibodies  >54 publications with COL4 and Muscular Dystrophies
 Disease Models, Animal Antibodies  >14 publications with COL4 and Disease Models, Animal
 Neoplasms Antibodies  >13 publications with COL4 and Neoplasms
 Fibrosis Antibodies  >8 publications with COL4 and Fibrosis
 Scleroatonic muscular dystrophy Antibodies  >8 publications with COL4 and Scleroatonic muscular dystrophy
 Inflammation Antibodies  >7 publications with COL4 and Inflammation
 Brain Diseases Antibodies  >6 publications with COL4 and Brain Diseases
 Heart Defects, Congenital Antibodies  >5 publications with COL4 and Heart Defects, Congenital
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >75 publications with COL4 and Muscle
 Skin Antibodies  >27 publications with COL4 and Skin
 Connective Tissue Antibodies  >18 publications with COL4 and Connective Tissue
 Bone Antibodies  >16 publications with COL4 and Bone
 Brain Antibodies  >11 publications with COL4 and Brain
 Heart Antibodies  >9 publications with COL4 and Heart
 Adipose Tissue Antibodies  >9 publications with COL4 and Adipose Tissue
 Blood Antibodies  >9 publications with COL4 and Blood
 Lung Antibodies  >7 publications with COL4 and Lung
 Vascular Antibodies  >6 publications with COL4 and Vascular
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