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| Product Name
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Collagen Type lV (COL4), ELISA Kit
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| Also Known As
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Canine Collagen Type lV ELISA Kit
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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| Request for Current Manual Insert
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| OMIM
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120220
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| 3D Structure
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ModBase 3D Structure for P12109
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| Species Reactivity
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Canine
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| Assay Type
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Sandwich
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| Preparation and Storage
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Store all reagents at 2-8 degree C
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| Product Note
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Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
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| Other Notes
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Small volumes of COL4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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| Searchable Terms for COL4 purchase
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MBS010428 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Collagen Type lV (COL4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COL4. The ELISA analytical biochemical technique of the MBS010428 kit is based on COL4 antibody-COL4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COL4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COL4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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| NCBI/Uniprot data below describe general gene information for COL4. It may not necessarily be applicable to this product. |
| NCBI GI #
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87196339
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| NCBI GeneID
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1291
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| NCBI Accession #
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NP_001839.2
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001848.2
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[Other Products]
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| UniProt Primary Accession #
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P12109
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[Other Products]
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| UniProt Secondary Accession #
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O00117; O00118; Q14040; Q14041; Q16258; Q7Z645; Q9BSA8
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[Other Products]
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| UniProt Related Accession #
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P12109
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[Other Products]
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| Molecular Weight
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108,529 Da
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| NCBI Official Full Name
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collagen alpha-1(VI) chain
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| NCBI Official Synonym Full Names
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collagen, type VI, alpha 1
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| NCBI Official Symbol
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COL6A1
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[Similar Products]
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| NCBI Official Synonym Symbols
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OPLL
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[Similar Products]
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| NCBI Protein Information
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collagen alpha-1(VI) chain; collagen alpha-1(VI) chain; alpha 1 (VI) chain (61 AA); collagen VI, alpha-1 polypeptide
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| UniProt Protein Name
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Collagen alpha-1(VI) chain
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| Protein Family
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Zinc finger protein CONSTANS
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| UniProt Gene Name
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COL6A1
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[Similar Products]
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| UniProt Entry Name
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CO6A1_HUMAN
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| NCBI Summary for COL4
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The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. [provided by RefSeq, Jul 2008]
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| UniProt Comments for COL4
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COL6A1: Collagen VI acts as a cell-binding protein. Defects in COL6A1 are a cause of Bethlem myopathy (BM). BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles. Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD); also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy. Belongs to the type VI collagen family.
Protein type: Secreted, signal peptide; Secreted; Extracellular matrix
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; protein complex; membrane; endoplasmic reticulum lumen; lysosomal membrane; extracellular region; sarcolemma; collagen type VI
Molecular Function: platelet-derived growth factor binding
Biological Process: osteoblast differentiation; axon guidance; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; cell adhesion
Disease: Bethlem Myopathy; Ullrich Congenital Muscular Dystrophy
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| Research Articles on COL4
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1. Mutations in each of the three collagen VI genes, COL6A1, COL6A2 and COL6A3, cause four types of muscle disorders: Ullrich congenital muscular dystrophy, Bethlem myopathy, limb-girdle muscular dystrophy, and autosomal recessive myosclerosis. (Review)
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with COL4 elisa kit | Pathways associated with COL4 elisa kit |
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| Diseases associated with COL4 elisa kit | Organs/Tissues associated with COL4 elisa kit |
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ELISA Kit 
