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Corin elisa kit :: Canine Corin (Atrial natriuretic peptide-converting enzyme) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS753915
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Corin (Atrial natriuretic peptide-converting enzyme), ELISA Kit

★Popular Item★
 Also Known As   

Canine Corin (Atrial natriuretic peptide-converting enzyme) ELISA Kit

 Product Gene Name   

Corin elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 4; NC_000004.11 (47596018..47840059, complement). Location: 4p13-p12
 OMIM    605236
 3D Structure    ModBase 3D Structure for Q9Y5Q5
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 Species Reactivity    Canine
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Corin. No significant cross-reactivity or interference between Corin and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between Corin and all the analogues, therefore, cross reaction may still exist in some cases.
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 Samples    Serum, plasma, cell culture supernatants, body fluid and tissue homogenate
 Assay Type    Competitive (Quantitative)
 Sensitivity    1.0 pg/mL.
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of Corin elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Corin purchase    MBS753915 is a ready-to-use microwell, strip plate Competitive (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Corin (Atrial natriuretic peptide-converting enzyme) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Corin, with an estimated sensitivity of 1.0 pg/mL. The ELISA analytical biochemical technique of the MBS753915 kit is based on Corin antibody-Corin antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Corin antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Corin. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, cell culture supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for Corin elisa kit

   Intended Uses: This Corin ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Canine Corin. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

Principle of the Assay: Corin ELISA kit applies the competitive enzyme immunoassay technique utilizing a monoclonal anti-Corin antibody and an Corin-HRP conjugate. The assay sample and buffer are incubated together with Corin-HRP conjugate in pre-coated plate for one hour. After the incubation period, the wells are decanted and washed five times. The wells are then incubated with a substrate for HRP enzyme. The product of the enzyme-substrate reaction forms a blue colored complex. Finally, a stop solution is added to stop the reaction, which will then turn the solution yellow. The intensity of color is measured spectrophotometrically at 450nm in a microplate reader. The intensity of the color is inversely proportional to the Corin concentration since Corin from samples and Corin-HRP conjugate compete for the anti-Corin antibody binding site. Since the number of sites is limited, as more sites are occupied by Corin from the sample, fewer sites are left to bind Corin-HRP conjugate. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The Corin concentration in each sample is interpolated from this standard curve.
 Product Categories/Family for Corin elisa kit    Cardiovascular
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 Typical Testing Data/Standard Curve (for reference only) of Corin elisa kit    Corin elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS753915. Click to request current manual
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NCBI/Uniprot data below describe general gene information for Corin. It may not necessarily be applicable to this product.
 NCBI GI #    4884872
 NCBI GeneID    10699
 NCBI Accession #    AAD31850.1 [Other Products]
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 UniProt Primary Accession #    Q9Y5Q5 [Other Products]
 UniProt Secondary Accession #    Q2TBD2; Q4W5E5; Q4W5G6; Q9UHY2; B0ZBE3 [Other Products]
 UniProt Related Accession #    Q9Y5Q5 [Other Products]
 Molecular Weight    116,486 Da
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 NCBI Official Full Name    corin
 NCBI Official Synonym Full Names    corin, serine peptidase
 NCBI Official Symbol    CORIN [Similar Products]
 NCBI Official Synonym Symbols   
CRN; ATC2; Lrp4; PEE5; TMPRSS10
[Similar Products]
 NCBI Protein Information    atrial natriuretic peptide-converting enzyme; pro-ANP-convertase; pro-ANP-converting enzyme; transmembrane protease serine 10; heart-specific serine proteinase ATC2
 UniProt Protein Name    Atrial natriuretic peptide-converting enzyme
 UniProt Synonym Protein Names   
Corin; Heart-specific serine proteinase ATC2; Pro-ANP-converting enzyme; Transmembrane protease serine 10
 Protein Family    Atrial natriuretic peptide-converting enzyme
 UniProt Gene Name    CORIN [Similar Products]
 UniProt Synonym Gene Names    CRN; TMPRSS10 [Similar Products]
 UniProt Entry Name    CORIN_HUMAN
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 NCBI Summary for Corin    This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
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 UniProt Comments for Corin    CORIN: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Defects in CORIN are the cause of pre-eclampsia/eclampsia 5 (PEE5); also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface; Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; integral to membrane; extracellular region

Molecular Function: serine-type endopeptidase activity

Biological Process: regulation of blood pressure; peptide hormone processing; female pregnancy; proteolysis; regulation of systemic arterial blood pressure by atrial natriuretic peptide

Disease: Preeclampsia/eclampsia 5
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 Research Articles on Corin    1. human CORIN gene mutations causing impaired corin activity may be an underlying mechanism in hypertension
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Corin elisa kitPathways associated with Corin elisa kit
 Reference Product  PubMed Publications
 NPPA elisa kit  >1 publications with Corin and NPPA
 Products by Pathway  Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
Diseases associated with Corin elisa kitOrgans/Tissues associated with Corin elisa kit
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >58 publications with Corin and Heart Diseases
 Hypertrophy Antibodies  >22 publications with Corin and Hypertrophy
 Cardiomegaly Antibodies  >21 publications with Corin and Cardiomegaly
 Neoplasms Antibodies  >19 publications with Corin and Neoplasms
 Brain Diseases Antibodies  >13 publications with Corin and Brain Diseases
 Nervous System Diseases Antibodies  >11 publications with Corin and Nervous System Diseases
 Carcinoma Antibodies  >9 publications with Corin and Carcinoma
 Fibrosis Antibodies  >8 publications with Corin and Fibrosis
 Kidney Diseases Antibodies  >7 publications with Corin and Kidney Diseases
 Congenital Abnormalities Antibodies  >5 publications with Corin and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >73 publications with Corin and Heart
 Muscle Antibodies  >40 publications with Corin and Muscle
 Eye Antibodies  >17 publications with Corin and Eye
 Bone Antibodies  >15 publications with Corin and Bone
 Connective Tissue Antibodies  >12 publications with Corin and Connective Tissue
 Skin Antibodies  >7 publications with Corin and Skin
 Embryonic Tissue Antibodies  >3 publications with Corin and Embryonic Tissue
 Uterus Antibodies  >2 publications with Corin and Uterus
 Intestine Antibodies  >1 publications with Corin and Intestine
 Testis Antibodies  >1 publications with Corin and Testis
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