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CRLF1 elisa kit :: Canine Cytokine receptor-like factor 1 (CRLF1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7202758 CRLF1 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytokine receptor-like factor 1 (CRLF1), ELISA Kit

 Also Known As   

Canine Cytokine receptor-like factor 1 (CRLF1) ELISA Kit

 Product Gene Name   

CRLF1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    604237
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 Species Reactivity    Canine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CRLF1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CRLF1 purchase    MBS7202758 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cytokine receptor-like factor 1 (CRLF1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CRLF1. The ELISA analytical biochemical technique of the MBS7202758 kit is based on CRLF1 antibody-CRLF1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CRLF1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CRLF1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for CRLF1 elisa kit    Immunology
NCBI/Uniprot data below describe general gene information for CRLF1. It may not necessarily be applicable to this product.
 NCBI GI #    4758062
 NCBI GeneID    9244
 NCBI Accession #    NP_004741.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004750.4 [Other Products]
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 UniProt Secondary Accession #    Q9UHH5 [Other Products]
 UniProt Related Accession #    O75462 [Other Products]
 Molecular Weight    46,302 Da
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 NCBI Official Full Name    cytokine receptor-like factor 1
 NCBI Official Synonym Full Names    cytokine receptor-like factor 1
 NCBI Official Symbol    CRLF1 [Similar Products]
 NCBI Official Synonym Symbols   
CLF; NR6; CISS; CISS1; CLF-1; zcytor5
[Similar Products]
 NCBI Protein Information    cytokine receptor-like factor 1; cytokine-like factor 1; class I cytokine receptor; cytokine type 1 receptor CRLP-1
 UniProt Protein Name    Cytokine receptor-like factor 1
 UniProt Synonym Protein Names   
Cytokine-like factor 1; CLF-1; ZcytoR5
 Protein Family    Cytokine receptor-like factor
 UniProt Gene Name    CRLF1 [Similar Products]
 UniProt Synonym Gene Names    UNQ288/PRO327; CLF-1 [Similar Products]
 UniProt Entry Name    CRLF1_HUMAN
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 NCBI Summary for CRLF1    This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
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 UniProt Comments for CRLF1    CRLF1: Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development. Defects in CRLF1 are the cause of cold-induced sweating syndrome type 1 (CISS1). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Defects in CRLF1 are the cause of Crisponi syndrome (CRISPS). Crisponi syndrome is a rare autosomal recessive disorder characterized by congenital muscular contractions of facial muscles, with trismus in response to stimuli, dysmorphic features, bilateral camptodactyly, major feeding and respiratory difficulties, and access of hyperthermia leading to death in the first months of life. Belongs to the type I cytokine receptor family. Type 3 subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: extracellular space

Molecular Function: protein binding; protein heterodimerization activity; cytokine binding; cytokine activity; receptor activity; ciliary neurotrophic factor receptor binding

Biological Process: ureteric bud development; positive regulation of cell proliferation; negative regulation of neuron apoptosis; positive regulation of tyrosine phosphorylation of Stat3 protein

Disease: Cold-induced Sweating Syndrome 1
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 Research Articles on CRLF1    1. The mutation detected in CRLF1 has not been described in patients with CISS1, but in one with CS. These data seem to support the theory that CS and CISS1 are variants of the same disorder.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CRLF1 elisa kitDiseases associated with CRLF1 elisa kit
 Reference Product  PubMed Publications
 CLCF1 elisa kit  >9 publications with CRLF1 and CLCF1
 CNTFR elisa kit  >4 publications with CRLF1 and CNTFR
 Disease Name  Pubmed Publications
 Crisponi syndrome Antibodies  >12 publications with CRLF1 and Crisponi syndrome
 Congenital Abnormalities Antibodies  >8 publications with CRLF1 and Congenital Abnormalities
 Skin Diseases Antibodies  >6 publications with CRLF1 and Skin Diseases
 Cardiovascular Diseases Antibodies  >2 publications with CRLF1 and Cardiovascular Diseases
 Fibrosis Antibodies  >2 publications with CRLF1 and Fibrosis
 Hypertrophy Antibodies  >1 publications with CRLF1 and Hypertrophy
 Disease Models, Animal Antibodies  >1 publications with CRLF1 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with CRLF1 and Inflammation
Organs/Tissues associated with CRLF1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >3 publications with CRLF1 and Skin
 Embryonic Tissue Antibodies  >2 publications with CRLF1 and Embryonic Tissue
 Brain Antibodies  >2 publications with CRLF1 and Brain
 Heart Antibodies  >1 publications with CRLF1 and Heart
 Lung Antibodies  >1 publications with CRLF1 and Lung
 Mouth Antibodies  >1 publications with CRLF1 and Mouth
 Liver Antibodies  >1 publications with CRLF1 and Liver
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