NP_001108105.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
114,121 Da
NCBI Official Full Name
cytosolic phospholipase A2 beta
NCBI Official Synonym Full Names
phospholipase A2, group IVB (cytosolic)
NCBI Protein Information
cytosolic phospholipase A2 beta
UniProt Protein Name
Cytosolic phospholipase A2 beta
UniProt Synonym Protein Names
Phospholipase A2 group IVB
UniProt Synonym Gene Names
UniProt Entry Name
PA24B_HUMAN
NCBI Summary for PLA2G4B
This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008]
UniProt Comments for PLA2G4B
PLA2G4B: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Not inhibited by pyrrolidine-2 and Wyeth-1. The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Four isoforms of the human protein are produced by alternative splicing. Isoform 3 translocates to membrane vesicles in a calcium-dependent fashion and has activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine.
Protein type: Phospholipase; Lipid Metabolism - arachidonic acid; EC 3.1.1.4
Chromosomal Location of Human Ortholog: 15q11.2-q21.3
Cellular Component: early endosome membrane; mitochondrial inner membrane; extracellular region; cytosol
Molecular Function: calcium-dependent phospholipid binding; calcium-dependent phospholipase A2 activity; calcium ion binding; lysophospholipase activity
Biological Process: cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; glycerophospholipid catabolic process; unfolded protein response; phospholipid metabolic process; glycerophospholipid biosynthetic process; calcium-mediated signaling; arachidonic acid metabolic process; phosphatidic acid biosynthetic process; parturition; inflammatory response
Research Articles on PLA2G4B
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Products associated with PLA2G4B elisa kit
Pathways associated with PLA2G4B elisa kit
Diseases associated with PLA2G4B elisa kit
Organs/Tissues associated with PLA2G4B elisa kit
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