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QDPR elisa kit :: Canine Dihydropteridine reductase (QDPR) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7245026 QDPR elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dihydropteridine reductase (QDPR), ELISA Kit

 Also Known As   

Canine Dihydropteridine reductase (QDPR) ELISA Kit

 Product Gene Name   

QDPR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    612676
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 Species Reactivity    Canine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of QDPR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for QDPR purchase    MBS7245026 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Dihydropteridine reductase (QDPR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing QDPR. The ELISA analytical biochemical technique of the MBS7245026 kit is based on QDPR antibody-QDPR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect QDPR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, QDPR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for QDPR. It may not necessarily be applicable to this product.
 NCBI GI #    208973246
 NCBI GeneID    5860
 NCBI Accession #    NP_000311.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000320.2 [Other Products]
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 UniProt Secondary Accession #    Q53F52; Q9H3M5; A8K158; B3KW71 [Other Products]
 UniProt Related Accession #    P09417 [Other Products]
 Molecular Weight    22,408 Da
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 NCBI Official Full Name    dihydropteridine reductase
 NCBI Official Synonym Full Names    quinoid dihydropteridine reductase
 NCBI Official Symbol    QDPR [Similar Products]
 NCBI Official Synonym Symbols   
DHPR; PKU2; SDR33C1
[Similar Products]
 NCBI Protein Information    dihydropteridine reductase; HDHPR; 6,7-dihydropteridine reductase; short chain dehydrogenase/reductase family 33C, member 1
 UniProt Protein Name    Dihydropteridine reductase
 UniProt Synonym Protein Names   
HDHPR; Quinoid dihydropteridine reductase
 Protein Family    Dihydropteridine reductase
 UniProt Gene Name    QDPR [Similar Products]
 UniProt Synonym Gene Names    DHPR [Similar Products]
 UniProt Entry Name    DHPR_HUMAN
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 NCBI Summary for QDPR    This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]
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 UniProt Comments for QDPR    QDPR: The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C); also called dihydropteridine reductase deficiency (DHPR deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to DHPR deficiency or quinoid dihydropteridine reductase deficiency (QDPR deficiency). HPABH4C is a rare autosomal recessive disorder characterized by hyperphenylalaninemia and severe neurologic symptoms (malignant hyperphenylalaninemia) including axial hypotonia and truncal hypertonia, abnormal thermogenesis, and microcephaly. These signs are attributable to depletion of the neurotransmitters dopamine and serotonin, whose syntheses are controlled by tryptophan and tyrosine hydroxylases that use BH-4 as cofactor. These patients do not respond to phenylalanine- restricted diet. HPABH4C is lethal if untreated. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Oxidoreductase; Cofactor and Vitamin Metabolism - folate biosynthesis; EC 1.5.1.34

Chromosomal Location of Human Ortholog: 4p15.31

Cellular Component: neuron projection; mitochondrion; cytoplasm; cytosol

Molecular Function: protein homodimerization activity; electron carrier activity; 6,7-dihydropteridine reductase activity

Biological Process: amino acid metabolic process; tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process; response to glucagon stimulus; dihydrobiopterin metabolic process; response to lead ion; liver development; response to aluminum ion

Disease: Hyperphenylalaninemia, Bh4-deficient, C
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 Research Articles on QDPR    1. JP1 and JP2 can facilitate the assembly of DHPR with other proteins of the excitation-contraction coupling machinery
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with QDPR elisa kitPathways associated with QDPR elisa kit
 Reference Product  PubMed Publications
 SPR elisa kit  >3 publications with QDPR and SPR
 PAH elisa kit  >3 publications with QDPR and PAH
 PCBD1 elisa kit  >1 publications with QDPR and PCBD1
 Products by Pathway  Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Phenylalanine And Tyrosine Catabolism Pathway antibodies  Phenylalanine And Tyrosine Catabolism Pathway Diagram
 Phenylalanine Degradation I (aerobic) Pathway antibodies  Phenylalanine Degradation I (aerobic) Pathway Diagram
 Phenylalanine Degradation I (aerobic) Pathway antibodies  Phenylalanine Degradation I (aerobic) Pathway Diagram
 Tetrahydrobiopterin Salvage Pathway antibodies  Tetrahydrobiopterin Salvage Pathway Diagram
Diseases associated with QDPR elisa kitOrgans/Tissues associated with QDPR elisa kit
 Disease Name  Pubmed Publications
 HYPERPHENYLALANINEMIA, BH4-DEFICIENT, C Antibodies  >6 publications with QDPR and HYPERPHENYLALANINEMIA, BH4-DEFICIENT, C
 Cognition Disorders Antibodies  >4 publications with QDPR and Cognition Disorders
 Abnormalities, Multiple Antibodies  >1 publications with QDPR and Abnormalities, Multiple
 Atrophy Antibodies  >1 publications with QDPR and Atrophy
 Fibrosis Antibodies  >1 publications with QDPR and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with QDPR and Blood
 Brain Antibodies  >4 publications with QDPR and Brain
 Kidney Antibodies  >2 publications with QDPR and Kidney
 Nerve Antibodies  >1 publications with QDPR and Nerve
 Lung Antibodies  >1 publications with QDPR and Lung
 Liver Antibodies  >1 publications with QDPR and Liver
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