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FGF23 elisa kit :: Canine Fibroblast Growth Factor 23 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2603786
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $300 +1 FREE 8GB USB
96-Strip-Wells  /  $475 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibroblast Growth Factor 23 (FGF23), ELISA Kit

★Popular Item★
 Also Known As   

Canine Fibroblast Growth Factor 23 (FGF23) ELISA Kit

 Product Gene Name   

FGF23 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    193100
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 Species Reactivity    Canine
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 Specificity    No cross-reaction with other factors.
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 Samples    Serum, plasma or cell culture supernatant and organizations in the natural and recombinant FGF23 concentration
 Assay Type    Sandwich
 Detection Range    1000 pg/ml-15.6pg/ml
 Sensitivity    5 pg/ml.
 Intra-assay Precision    ? 8%
 Inter-assay Precision    ? 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FGF23 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FGF23 purchase    MBS2603786 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Fibroblast Growth Factor 23 (FGF23) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1000 pg/ml-15.6pg/ml in biological research samples containing FGF23, with an estimated sensitivity of 5 pg/ml. The ELISA analytical biochemical technique of the MBS2603786 kit is based on FGF23 antibody-FGF23 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FGF23 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FGF23. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma or cell culture supernatant and organizations in the natural and recombinant FGF23 concentration. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for FGF23 elisa kit

   Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Canine FGF23 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve (for reference only) of FGF23 elisa kit    FGF23 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2603786. Click to request current manual
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NCBI/Uniprot data below describe general gene information for FGF23. It may not necessarily be applicable to this product.
 NCBI GI #    10190674
 NCBI GeneID    8074
 NCBI Accession #    NP_065689.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020638.2 [Other Products]
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 UniProt Secondary Accession #    Q4V758 [Other Products]
 UniProt Related Accession #    Q9GZV9 [Other Products]
 Molecular Weight    27,954 Da
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 NCBI Official Full Name    fibroblast growth factor 23
 NCBI Official Synonym Full Names    fibroblast growth factor 23
 NCBI Official Symbol    FGF23 [Similar Products]
 NCBI Official Synonym Symbols   
ADHR; FGFN; HYPF; HPDR2; PHPTC
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 23
 UniProt Protein Name    Fibroblast growth factor 23
 UniProt Synonym Protein Names   
Phosphatonin; Tumor-derived hypophosphatemia-inducing factor
 Protein Family    Fibroblast growth factor
 UniProt Gene Name    FGF23 [Similar Products]
 UniProt Synonym Gene Names    HYPF; FGF-23 [Similar Products]
 UniProt Entry Name    FGF23_HUMAN
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 NCBI Summary for FGF23    This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
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 UniProt Comments for FGF23    FGF23: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR). ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses. Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Belongs to the heparin-binding growth factors family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: extracellular region; extracellular space; intracellular

Molecular Function: growth factor activity; type 1 fibroblast growth factor receptor binding

Biological Process: activation of MAPKK activity; axon guidance; cellular phosphate ion homeostasis; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of bone mineralization; negative regulation of hormone secretion; negative regulation of osteoblast differentiation; nerve growth factor receptor signaling pathway; phosphate ion homeostasis; phosphoinositide-mediated signaling; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; response to magnesium ion; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway; vitamin D catabolic process

Disease: Hypophosphatemic Rickets, Autosomal Dominant
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 Research Articles on FGF23    1. The study finds a strong association between red cell distribution width and fibroblast Growth Factor 23 cleaving in patients with chronic kidney disease and heart failure.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FGF23 elisa kitPathways associated with FGF23 elisa kit
 Reference Product  PubMed Publications
 PTH elisa kit  >312 publications with FGF23 and PTH
 PHEX elisa kit  >117 publications with FGF23 and PHEX
 FGFR1 elisa kit  >57 publications with FGF23 and FGFR1
 GALNT3 elisa kit  >51 publications with FGF23 and GALNT3
 FGFR4 elisa kit  >15 publications with FGF23 and FGFR4
 FGFR3 elisa kit  >14 publications with FGF23 and FGFR3
 FGFR2 elisa kit  >11 publications with FGF23 and FGFR2
 FGF1 elisa kit  >8 publications with FGF23 and FGF1
 FGF9 elisa kit  >5 publications with FGF23 and FGF9
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with FGF23 elisa kitOrgans/Tissues associated with FGF23 elisa kit
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >561 publications with FGF23 and Kidney Diseases
 Rickets Antibodies  >309 publications with FGF23 and Rickets
 Phosphorus Metabolism Disorders Antibodies  >307 publications with FGF23 and Phosphorus Metabolism Disorders
 Renal Insufficiency Antibodies  >266 publications with FGF23 and Renal Insufficiency
 Hyperphosphatemia Antibodies  >180 publications with FGF23 and Hyperphosphatemia
 Calcinosis Antibodies  >132 publications with FGF23 and Calcinosis
 Hypertension Antibodies  >104 publications with FGF23 and Hypertension
 Hypertrophy Antibodies  >59 publications with FGF23 and Hypertrophy
 Death Antibodies  >55 publications with FGF23 and Death
 Osteoporosis Antibodies  >42 publications with FGF23 and Osteoporosis
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >17 publications with FGF23 and Embryonic Tissue
 Testis Antibodies  >2 publications with FGF23 and Testis
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