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FRA elisa kit :: Canine Fibronection Related Antigen ELISA Kit

Scan QR to view Datasheet Catalog #    MBS016095 FRA elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibronection Related Antigen (FRA), ELISA Kit

 Also Known As   

Canine Fibronection Related Antigen ELISA Kit

 Product Gene Name   

FRA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    136515
 3D Structure    ModBase 3D Structure for P15407
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 Species Reactivity    Canine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FRA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FRA purchase    MBS016095 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Fibronection Related Antigen (FRA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FRA. The ELISA analytical biochemical technique of the MBS016095 kit is based on FRA antibody-FRA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FRA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FRA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for FRA. It may not necessarily be applicable to this product.
 NCBI GI #    664806071
 NCBI GeneID    8061
 NCBI Accession #    NP_001287773.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001300844.1 [Other Products]
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 UniProt Primary Accession #    P15407 [Other Products]
 UniProt Secondary Accession #    Q6FG51 [Other Products]
 UniProt Related Accession #    P15407 [Other Products]
 Molecular Weight    29,413 Da
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 NCBI Official Full Name    fos-related antigen 1 isoform 2
 NCBI Official Synonym Full Names    FOS-like antigen 1
 NCBI Official Symbol    FOSL1 [Similar Products]
 NCBI Official Synonym Symbols   
FRA; FRA1; fra-1
[Similar Products]
 NCBI Protein Information    fos-related antigen 1; FOS-like antigen-1
 UniProt Protein Name    Fos-related antigen 1
 Protein Family    Intracellular iron chaperone frataxin
 UniProt Gene Name    FOSL1 [Similar Products]
 UniProt Synonym Gene Names    FRA1; FRA-1 [Similar Products]
 UniProt Entry Name    FOSL1_HUMAN
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 NCBI Summary for FRA    The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
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 UniProt Comments for FRA    FRA1: an oncogenic transcription factor of the bZIP family, Fos subfamily. The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins (c-Jun, JunB, and JunD) to form Activator Protein-1 (AP-1), a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-zipper motif that mediates dimerization and an adjacent basic domain that binds to DNA. The various Fos/Jun heterodimers differ in their ability to transactivate AP-1 dependent genes. In addition to increased expression, phosphorylation of Fos proteins by Erk kinases in response to extracellular stimuli may further increase transcriptional activity. Following growth factor stimulation, expression of FosB and c-Fos in quiescent fibroblasts is immediate but short-lived, while FRA1 and FRA2 expression persists longer. FRA1 is involved in cell motility, invasiveness, and inhibits apoptosis. Elevated in many cancers and associated with tumorigenesis and cancer progression. Involved in Erk2-mediated Epithelial-to-Mesenchymal Transition (EMT) pathway. ERK2/FRA2 regulate ZEB1/2 expression, known to be associated with the EMT. Smad2/3-Fra1 complexes may reflect activation of the Smad/AP-1-dependent TGF¿-induced breast cancer invasion program. Activation of FRA1/C-JUN by ERK/AKT pathways can induce EZH2 overexpression, silencing integrin alpha-2 expression, and increasing the metastatic potential of colorectal cancer. Belongs to the bZIP family. Fos subfamily.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: presynaptic membrane; nucleoplasm; neuron projection; cytosol; nucleus

Molecular Function: protein binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; response to drug; response to gravity; response to cAMP; in utero embryonic development; positive regulation of apoptosis; response to virus; vitellogenesis; positive regulation of cell cycle; learning; female pregnancy; chemotaxis; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; positive regulation of cell proliferation; cellular response to extracellular stimulus; cellular defense response; positive regulation of transcription factor activity; response to progesterone stimulus; response to corticosterone stimulus
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 Research Articles on FRA    1. Data indicate that estrogen induced the expression of c-Jun, Fra-1, c-Fos, cyclin D1 and cyclin E1 while tamoxifen (TMX) decreased the expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FRA elisa kitPathways associated with FRA elisa kit
 Reference Product  PubMed Publications
 JUN elisa kit  >14 publications with FRA and JUN
 MYC elisa kit  >10 publications with FRA and MYC
 JUND elisa kit  >6 publications with FRA and JUND
 JUNB elisa kit  >4 publications with FRA and JUNB
 MMP9 elisa kit  >3 publications with FRA and MMP9
 CCND1 elisa kit  >2 publications with FRA and CCND1
 MMP1 elisa kit  >1 publications with FRA and MMP1
 Products by Pathway  Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram
Diseases associated with FRA elisa kitOrgans/Tissues associated with FRA elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >28 publications with FRA and Neoplasms
 Breast Neoplasms Antibodies  >7 publications with FRA and Breast Neoplasms
 Lung Diseases Antibodies  >6 publications with FRA and Lung Diseases
 Necrosis Antibodies  >6 publications with FRA and Necrosis
 Neoplasms, Experimental Antibodies  >5 publications with FRA and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >5 publications with FRA and Disease Models, Animal
 Nervous System Diseases Antibodies  >4 publications with FRA and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >4 publications with FRA and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with FRA and Cell Transformation, Neoplastic
 Inflammation Antibodies  >3 publications with FRA and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >18 publications with FRA and Bone
 Blood Antibodies  >12 publications with FRA and Blood
 Lung Antibodies  >7 publications with FRA and Lung
 Skin Antibodies  >7 publications with FRA and Skin
 Brain Antibodies  >6 publications with FRA and Brain
 Vascular Antibodies  >6 publications with FRA and Vascular
 Bone Marrow Antibodies  >5 publications with FRA and Bone Marrow
 Mouth Antibodies  >2 publications with FRA and Mouth
 Placenta Antibodies  >2 publications with FRA and Placenta
 Kidney Antibodies  >2 publications with FRA and Kidney
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