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FBLN5 elisa kit :: Canine Fibulin 5 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS744054 FBLN5 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibulin 5 (FBLN5), ELISA Kit

 Also Known As   

Canine Fibulin 5 ELISA Kit

 Product Gene Name   

FBLN5 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    614434
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 Species Reactivity    Canine
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FBLN5 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FBLN5 purchase    MBS744054 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Fibulin 5 (FBLN5) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FBLN5. The ELISA analytical biochemical technique of the MBS744054 kit is based on FBLN5 antibody-FBLN5 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FBLN5 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FBLN5. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for FBLN5 elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for FBLN5. It may not necessarily be applicable to this product.
 NCBI GI #    19743803
 NCBI GeneID    10516
 NCBI Accession #    NP_006320.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006329.3 [Other Products]
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 UniProt Secondary Accession #    O75966; Q6IAL4; Q6UWA3 [Other Products]
 UniProt Related Accession #    Q9UBX5 [Other Products]
 Molecular Weight    50,180 Da
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 NCBI Official Full Name    fibulin-5
 NCBI Official Synonym Full Names    fibulin 5
 NCBI Official Symbol    FBLN5 [Similar Products]
 NCBI Official Synonym Symbols   
EVEC; UP50; ADCL2; ARMD3; DANCE; ARCL1A; FIBL-5
[Similar Products]
 NCBI Protein Information    fibulin-5; urine p50 protein; developmental arteries and neural crest EGF-like protein
 UniProt Protein Name    Fibulin-5
 UniProt Synonym Protein Names   
Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50
 Protein Family    Fibulin
 UniProt Gene Name    FBLN5 [Similar Products]
 UniProt Synonym Gene Names    DANCE; UNQ184/PRO210; FIBL-5; Dance; UP50 [Similar Products]
 UniProt Entry Name    FBLN5_HUMAN
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 NCBI Summary for FBLN5    The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
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 UniProt Comments for FBLN5    FBLN5: Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling. Defects in FBLN5 are the cause of cutis laxa, autosomal dominant, type 2 (ADCL2). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Defects in FBLN5 are a cause of cutis laxa, autosomal recessive, type 1A (ARCL1A). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. Type I autosomal recessive cutis laxa is a specific, life-threatening disorder with organ involvement, lung atelectasis and emphysema, diverticula of the gastrointestinal and genitourinary systems, and vascular anomalies. Associated cranial anomalies, late closure of the fontanel, joint laxity, hip dislocation, and inguinal hernia have been observed but are uncommon. Defects in FBLN5 are the cause of age-related macular degeneration type 3 (ARMD3). ARMD is a multifactorial disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the fibulin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: integrin binding; protein C-terminus binding; protein binding; protein homodimerization activity; calcium ion binding

Biological Process: elastic fiber assembly; extracellular matrix organization and biogenesis; secretion; cell-matrix adhesion; regulation of cell growth

Disease: Cutis Laxa, Autosomal Dominant 2; Macular Degeneration, Age-related, 3; Cutis Laxa, Autosomal Recessive, Type Ia
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 Research Articles on FBLN5    1. fibulin-5 overexpression in NPC specimens correlated with advanced tumor metastasis indicating a poor 5-year overall survival
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FBLN5 elisa kitPathways associated with FBLN5 elisa kit
 Reference Product  PubMed Publications
 LOXL1 elisa kit  >10 publications with FBLN5 and LOXL1
 ELN elisa kit  >4 publications with FBLN5 and ELN
 VEGFA elisa kit  >3 publications with FBLN5 and VEGFA
 TGFB1 elisa kit  >3 publications with FBLN5 and TGFB1
 MMP7 elisa kit  >1 publications with FBLN5 and MMP7
 SOD3 elisa kit  >1 publications with FBLN5 and SOD3
 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Molecules Associated With Elastic Fibres Pathway antibodies  Molecules Associated With Elastic Fibres Pathway Diagram
Diseases associated with FBLN5 elisa kitOrgans/Tissues associated with FBLN5 elisa kit
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >11 publications with FBLN5 and Vascular Diseases
 Heart Diseases Antibodies  >10 publications with FBLN5 and Heart Diseases
 Disease Models, Animal Antibodies  >8 publications with FBLN5 and Disease Models, Animal
 Emphysema Antibodies  >7 publications with FBLN5 and Emphysema
 Nervous System Diseases Antibodies  >7 publications with FBLN5 and Nervous System Diseases
 Lung Injury Antibodies  >5 publications with FBLN5 and Lung Injury
 Inflammation Antibodies  >4 publications with FBLN5 and Inflammation
 Neoplasm Metastasis Antibodies  >3 publications with FBLN5 and Neoplasm Metastasis
 Macular Degeneration, Age-Related, 3 Antibodies  >2 publications with FBLN5 and Macular Degeneration, Age-Related, 3
 CUTIS LAXA, AUTOSOMAL DOMINANT 1 Antibodies  >2 publications with FBLN5 and CUTIS LAXA, AUTOSOMAL DOMINANT 1
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >53 publications with FBLN5 and Connective Tissue
 Skin Antibodies  >42 publications with FBLN5 and Skin
 Vascular Antibodies  >37 publications with FBLN5 and Vascular
 Muscle Antibodies  >25 publications with FBLN5 and Muscle
 Lung Antibodies  >21 publications with FBLN5 and Lung
 Heart Antibodies  >12 publications with FBLN5 and Heart
 Embryonic Tissue Antibodies  >11 publications with FBLN5 and Embryonic Tissue
 Bone Antibodies  >7 publications with FBLN5 and Bone
 Kidney Antibodies  >6 publications with FBLN5 and Kidney
 Eye Antibodies  >6 publications with FBLN5 and Eye
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