NP_963853.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,406 Da
NCBI Official Full Name
forkhead box protein O3
NCBI Official Synonym Full Names
forkhead box O3
NCBI Official Synonym Symbols
FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2 [Similar Products]
NCBI Protein Information
forkhead box protein O3
UniProt Protein Name
Forkhead box protein O3
UniProt Synonym Protein Names
AF6q21 protein
UniProt Entry Name
FOXO3_HUMAN
NCBI Summary for FOXO3A
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for FOXO3A
FOXO3A: a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia.
Protein type: DNA-binding; Oncoprotein; Autophagy; Transcription factor
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus
Molecular Function: beta-catenin binding; chromatin DNA binding; DNA binding; protein binding; protein kinase binding; sequence-specific DNA binding; transcription factor activity
Biological Process: anatomical structure morphogenesis; antral ovarian follicle growth; cell differentiation; DNA damage response, signal transduction by p53 class mediator; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; glucose homeostasis; initiation of primordial ovarian follicle growth; innate immune response; negative regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; oocyte maturation; ovulation from ovarian follicle; phosphoinositide-mediated signaling; positive regulation of apoptosis; positive regulation of erythrocyte differentiation; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; regulation of translation; transcription from RNA polymerase II promoter; tumor necrosis factor-mediated signaling pathway
Research Articles on FOXO3A
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Products associated with FOXO3A elisa kit
Pathways associated with FOXO3A elisa kit
Diseases associated with FOXO3A elisa kit
Organs/Tissues associated with FOXO3A elisa kit
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