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FOXL2 elisa kit :: Canine Forkhead box protein L2 (FOXL2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7200093 FOXL2 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Forkhead box protein L2 (FOXL2), ELISA Kit

 Also Known As   

Canine Forkhead box protein L2 (FOXL2) ELISA Kit

 Product Gene Name   

FOXL2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 608996
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 Species Reactivity    Canine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FOXL2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FOXL2 purchase    MBS7200093 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Forkhead box protein L2 (FOXL2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FOXL2. The ELISA analytical biochemical technique of the MBS7200093 kit is based on FOXL2 antibody-FOXL2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FOXL2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FOXL2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for FOXL2 elisa kit    Epigenetics and Nuclear Signaling
NCBI/Uniprot data below describe general gene information for FOXL2. It may not necessarily be applicable to this product.
 NCBI GI #    12751477
 NCBI GeneID    668
 NCBI Accession #    NP_075555.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_023067.3 [Other Products]
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 UniProt Secondary Accession #    Q4ZGJ3 [Other Products]
 UniProt Related Accession #    P58012 [Other Products]
 Molecular Weight    38,772 Da
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 NCBI Official Full Name    forkhead box protein L2
 NCBI Official Synonym Full Names    forkhead box L2
 NCBI Official Symbol    FOXL2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    forkhead box protein L2; forkhead transcription factor FOXL2
 UniProt Protein Name    Forkhead box protein L2
 Protein Family    Forkhead box protein
 UniProt Gene Name    FOXL2 [Similar Products]
 UniProt Entry Name    FOXL2_HUMAN
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 NCBI Summary for FOXL2    This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jun 2009]
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 UniProt Comments for FOXL2    FOXL2: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Is a regulator of CYP19 expression. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element. Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Defects in FOXL2 are a cause of blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES); also known as blepharophimosis syndrome. It is an autosomal dominant disorder characterized by eyelid dysplasia, small palpebral fissures, drooping eyelids and a skin fold running inward and upward from the lower lid. In type I BPSE (BPES1) eyelid abnormalities are associated with female infertility. Affected females show an ovarian deficit due to primary amenorrhea or to premature ovarian failure (POF). In type II BPSE (BPES2) affected individuals show only the eyelid defects. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II. Defects in FOXL2 are a cause of premature ovarian failure type 3 (POF3). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: nucleus

Molecular Function: protein binding; DNA binding; ubiquitin conjugating enzyme binding; sequence-specific DNA binding; caspase regulator activity; estrogen receptor binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; positive regulation of apoptosis; embryonic eye morphogenesis; positive regulation of transcription, DNA-dependent; female somatic sex determination; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; ovarian follicle development; positive regulation of transcription from RNA polymerase II promoter; DNA fragmentation during apoptosis; negative regulation of transcription, DNA-dependent; cell differentiation; extraocular skeletal muscle development; menstruation; granulosa cell differentiation

Disease: Blepharophimosis, Ptosis, And Epicanthus Inversus; Premature Ovarian Failure 3
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 Research Articles on FOXL2    1. The molecular interactions of FOXL2, GATA4, and SMAD3 and their roles in the regulation of CCND2 using co-immunoprecipitation, promoter transactivation, and cell viability assays in human granulosa cell tumor cells, were investigated.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FOXL2 elisa kitDiseases associated with FOXL2 elisa kit
 Reference Product  PubMed Publications
 CYP19A1 elisa kit  >65 publications with FOXL2 and CYP19A1
 SOX9 elisa kit  >62 publications with FOXL2 and SOX9
 RSPO1 elisa kit  >20 publications with FOXL2 and RSPO1
 NR5A1 elisa kit  >16 publications with FOXL2 and NR5A1
 SMAD3 elisa kit  >12 publications with FOXL2 and SMAD3
 SIRT1 elisa kit  >2 publications with FOXL2 and SIRT1
 GNRHR elisa kit  >2 publications with FOXL2 and GNRHR
 MRPS22 elisa kit  >1 publications with FOXL2 and MRPS22
 LHX4 elisa kit  >1 publications with FOXL2 and LHX4
 DDX20 elisa kit  >1 publications with FOXL2 and DDX20
 Disease Name  Pubmed Publications
 Urogenital Abnormalities Antibodies  >37 publications with FOXL2 and Urogenital Abnormalities
 Premature Ovarian Failure 3 Antibodies  >29 publications with FOXL2 and Premature Ovarian Failure 3
 Chromosome Aberrations Antibodies  >22 publications with FOXL2 and Chromosome Aberrations
 Infertility, Male Antibodies  >8 publications with FOXL2 and Infertility, Male
 Neurobehavioral Manifestations Antibodies  >7 publications with FOXL2 and Neurobehavioral Manifestations
 Blepharophimosis, Ptosis, and Epicanthus Inversus Antibodies  >7 publications with FOXL2 and Blepharophimosis, Ptosis, and Epicanthus Inversus
 Blepharophimosis syndrome type 1 Antibodies  >6 publications with FOXL2 and Blepharophimosis syndrome type 1
 Cardiovascular Diseases Antibodies  >5 publications with FOXL2 and Cardiovascular Diseases
 Microcephaly Antibodies  >4 publications with FOXL2 and Microcephaly
 Colorectal Neoplasms Antibodies  >3 publications with FOXL2 and Colorectal Neoplasms
Organs/Tissues associated with FOXL2 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >218 publications with FOXL2 and Ovary
 Brain Antibodies  >31 publications with FOXL2 and Brain
 Heart Antibodies  >5 publications with FOXL2 and Heart
 Uterus Antibodies  >3 publications with FOXL2 and Uterus
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