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SAR1B elisa kit :: Canine GTP-binding protein SAR1b (SAR1B) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7245650 SAR1B elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GTP-binding protein SAR1b (SAR1B), ELISA Kit

 Also Known As   

Canine GTP-binding protein SAR1b (SAR1B) ELISA Kit

 Product Gene Name   

SAR1B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    607690
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 Species Reactivity    Canine
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SAR1B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SAR1B purchase    MBS7245650 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the GTP-binding protein SAR1b (SAR1B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SAR1B. The ELISA analytical biochemical technique of the MBS7245650 kit is based on SAR1B antibody-SAR1B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SAR1B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SAR1B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for SAR1B elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for SAR1B. It may not necessarily be applicable to this product.
 NCBI GI #    75709204
 NCBI GeneID    51128
 NCBI Accession #    NP_001028675.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001033503.2 [Other Products]
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 UniProt Secondary Accession #    Q567T4; D3DQA4 [Other Products]
 UniProt Related Accession #    Q9Y6B6 [Other Products]
 Molecular Weight    22,410 Da
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 NCBI Official Full Name    GTP-binding protein SAR1b
 NCBI Official Synonym Full Names    secretion associated, Ras related GTPase 1B
 NCBI Official Symbol    SAR1B [Similar Products]
 NCBI Official Synonym Symbols   
ANDD; CMRD; GTBPB; SARA2
[Similar Products]
 NCBI Protein Information    GTP-binding protein SAR1b; 2310075M17Rik; SAR1 homolog B; SAR1a gene homolog 2; GTP-binding protein B; GTP-binding protein Sara
 UniProt Protein Name    GTP-binding protein SAR1b
 UniProt Synonym Protein Names   
GTP-binding protein B; GTBPB
 Protein Family    GTP-binding protein
 UniProt Gene Name    SAR1B [Similar Products]
 UniProt Synonym Gene Names    SARA2; SARB; GTBPB [Similar Products]
 UniProt Entry Name    SAR1B_HUMAN
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 NCBI Summary for SAR1B    The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
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 UniProt Comments for SAR1B    SAR1B: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD); also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Belongs to the small GTPase superfamily. SAR1 family.

Protein type: G protein; Motility/polarity/chemotaxis; G protein, monomeric; G protein, monomeric, SAR1

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: endoplasmic reticulum membrane; cytosol

Molecular Function: GTPase activity; GTP binding; metal ion binding

Biological Process: COPII coating of Golgi vesicle; intracellular protein transport; ER to Golgi vesicle-mediated transport; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification

Disease: Chylomicron Retention Disease
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 Research Articles on SAR1B    1. although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SAR1B elisa kitPathways associated with SAR1B elisa kit
 Reference Product  PubMed Publications
 APOB elisa kit  >5 publications with SAR1B and APOB
 SEC13 elisa kit  >5 publications with SAR1B and SEC13
 SEC23A elisa kit  >5 publications with SAR1B and SEC23A
 MTTP elisa kit  >2 publications with SAR1B and MTTP
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 COPII Complex Pathway antibodies  COPII Complex Pathway Diagram
 COPII Complex Pathway antibodies  COPII Complex Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 ER To Golgi Transport Pathway antibodies  ER To Golgi Transport Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with SAR1B elisa kitOrgans/Tissues associated with SAR1B elisa kit
 Disease Name  Pubmed Publications
 Chylomicron retention disease Antibodies  >17 publications with SAR1B and Chylomicron retention disease
 Nervous System Diseases Antibodies  >7 publications with SAR1B and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with SAR1B and Brain Diseases
 Fatty Liver Antibodies  >3 publications with SAR1B and Fatty Liver
 Abnormalities, Multiple Antibodies  >2 publications with SAR1B and Abnormalities, Multiple
 Atrophy Antibodies  >1 publications with SAR1B and Atrophy
 Blood Coagulation Disorders Antibodies  >1 publications with SAR1B and Blood Coagulation Disorders
 Heart Defects, Congenital Antibodies  >1 publications with SAR1B and Heart Defects, Congenital
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >8 publications with SAR1B and Intestine
 Liver Antibodies  >8 publications with SAR1B and Liver
 Blood Antibodies  >7 publications with SAR1B and Blood
 Heart Antibodies  >4 publications with SAR1B and Heart
 Bone Antibodies  >4 publications with SAR1B and Bone
 Muscle Antibodies  >3 publications with SAR1B and Muscle
 Brain Antibodies  >3 publications with SAR1B and Brain
 Lung Antibodies  >2 publications with SAR1B and Lung
 Stomach Antibodies  >1 publications with SAR1B and Stomach
 Placenta Antibodies  >1 publications with SAR1B and Placenta
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