NP_001159719.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,112 Da
NCBI Official Full Name
glutamate receptor ionotropic, kainate 2 isoform 3
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, kainate 2
NCBI Official Synonym Symbols
EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2 [Similar Products]
NCBI Protein Information
glutamate receptor ionotropic, kainate 2; gluR-6; bA487F5.1; glutamate receptor 6; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; excitatory amino acid receptor 4
UniProt Protein Name
Glutamate receptor ionotropic, kainate 2
UniProt Synonym Protein Names
Excitatory amino acid receptor 4; EAA4; Glutamate receptor 6; GluR-6; GluR6
UniProt Synonym Gene Names
UniProt Entry Name
GRIK2_HUMAN
NCBI Summary for GRIK2
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]
UniProt Comments for GRIK2
GluR6: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2. Defects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6). It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, calcium; Channel, ligand-gated; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q16.3
Cellular Component: dendrite cytoplasm; presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; dendrite; postsynaptic density; plasma membrane; terminal button; perikaryon; cell junction
Molecular Function: protein homodimerization activity; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding; PDZ domain binding
Biological Process: regulation of long-term neuronal synaptic plasticity; regulation of synaptic transmission; synaptic transmission, glutamatergic; behavioral fear response; glutamate signaling pathway; negative regulation of synaptic transmission, glutamatergic; generation of action potential; regulation of short-term neuronal synaptic plasticity; receptor clustering; regulation of JNK cascade; positive regulation of synaptic transmission; cellular calcium ion homeostasis; synaptic transmission; intracellular protein transport; regulation of inhibitory postsynaptic membrane potential; neuron apoptosis; transport; ionotropic glutamate receptor signaling pathway; positive regulation of neuron apoptosis; negative regulation of neuron apoptosis; regulation of excitatory postsynaptic membrane potential
Disease: Mental Retardation, Autosomal Recessive 6
Research Articles on GRIK2
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Pathways associated with GRIK2 elisa kit
Diseases associated with GRIK2 elisa kit
Organs/Tissues associated with GRIK2 elisa kit
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