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HJV elisa kit :: Canine Hemojuvelin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS027461 HJV elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hemojuvelin (HJV), ELISA Kit

 Also Known As   

Canine Hemojuvelin ELISA Kit

 Product Gene Name   

HJV elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 3; NC_000069.6 (96525185..96529216). Location: 3 F2.1; 3
 3D Structure    ModBase 3D Structure for Q7TQ32
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 Species Reactivity    Canine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HJV elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HJV purchase    MBS027461 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Hemojuvelin (HJV) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HJV. The ELISA analytical biochemical technique of the MBS027461 kit is based on HJV antibody-HJV antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HJV antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HJV. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for HJV. It may not necessarily be applicable to this product.
 NCBI GI #    166295198
 NCBI GeneID    69585
 NCBI Accession #    NP_081402.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_027126.4 [Other Products]
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 UniProt Primary Accession #    Q7TQ32 [Other Products]
 UniProt Secondary Accession #    Q8CEU7; Q8K1D4; Q9D741 [Other Products]
 UniProt Related Accession #    Q7TQ32 [Other Products]
 Molecular Weight    44,848 Da
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 NCBI Official Full Name    hemojuvelin
 NCBI Official Synonym Full Names    hemochromatosis type 2 (juvenile) (human homolog)
 NCBI Official Symbol    Hfe2 [Similar Products]
 NCBI Official Synonym Symbols   
HJV; DL-M; Rgmc; AI414844; AI789733; hemojuvelin; 2310035L15Rik; 5230400G09Rik
[Similar Products]
 NCBI Protein Information    hemojuvelin; RGM domain family member C; repulsive guidance molecule C; hemochromatosis type 2 protein homolog
 UniProt Protein Name    Hemojuvelin
 UniProt Synonym Protein Names   
Hemochromatosis type 2 protein homolog; RGM domain family member C
 Protein Family    Hemojuvelin
 UniProt Gene Name    Hfe2 [Similar Products]
 UniProt Synonym Gene Names    Rgmc [Similar Products]
 UniProt Entry Name    RGMC_MOUSE
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 UniProt Comments for HJV    HFE2: Member of the repulsive guidance molecule (RGM) family. Involved in iron metabolism. Acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. May cooperate with hepcidin to restrict iron absorption in the gut. Could represent the cellular receptor for hepcidin. Defects in HFE2 are the cause of hemochromatosis type 2A (HFE2A); also known as juvenile hemochromatosis (JH). HFE2A is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. It is the consequence of intestinal iron hyperabsorption associated with macrophages that do not load iron. Deleterious mutations of HFE2 reduced HAMP (hepcidin) levels despite iron overload, which normally induces HAMP expression. Belongs to the repulsive guidance molecule (RGM) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor

Cellular Component: extracellular space; cell surface; membrane; basolateral plasma membrane; plasma membrane

Molecular Function: protein binding; coreceptor activity

Biological Process: BMP signaling pathway; iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of BMP signaling pathway
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 Research Articles on HJV    1. Use of proteomic analysis enables identification of four disulfide linkages in hemojuvelin/repulsive guidance molecule C. This molecule is a single-chain HJV/RGMc isoform.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HJV elisa kitDiseases associated with HJV elisa kit
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Iron Homeostasis Pathway antibodies  Iron Homeostasis Pathway Diagram
 Netrin-1 Signaling Pathway antibodies  Netrin-1 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Hemochromatosis Antibodies  >112 publications with HJV and Hemochromatosis
 Anemia Antibodies  >26 publications with HJV and Anemia
 Liver Diseases Antibodies  >21 publications with HJV and Liver Diseases
 Inflammation Antibodies  >15 publications with HJV and Inflammation
 Neoplasms Antibodies  >5 publications with HJV and Neoplasms
 Carcinoma, Hepatocellular Antibodies  >5 publications with HJV and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >5 publications with HJV and Heart Diseases
 Drug Toxicity Antibodies  >4 publications with HJV and Drug Toxicity
 Disease Models, Animal Antibodies  >4 publications with HJV and Disease Models, Animal
 Liver Neoplasms Antibodies  >4 publications with HJV and Liver Neoplasms
Organs/Tissues associated with HJV elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >86 publications with HJV and Liver
 Muscle Antibodies  >22 publications with HJV and Muscle
 Heart Antibodies  >19 publications with HJV and Heart
 Brain Antibodies  >4 publications with HJV and Brain
 Eye Antibodies  >3 publications with HJV and Eye
 Connective Tissue Antibodies  >2 publications with HJV and Connective Tissue
 Embryonic Tissue Antibodies  >1 publications with HJV and Embryonic Tissue
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