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HK2 elisa kit :: Canine Hexokinase 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS010199 HK2 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hexokinase 2 (HK2), ELISA Kit

 Also Known As   

Canine Hexokinase 2 ELISA Kit

 Product Gene Name   

HK2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 2; NC_000002.11 (75059782..75120481). Location: 2p13
 OMIM    601125
 3D Structure    ModBase 3D Structure for P52789
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 Species Reactivity    Canine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HK2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HK2 purchase    MBS010199 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Hexokinase 2 (HK2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HK2. The ELISA analytical biochemical technique of the MBS010199 kit is based on HK2 antibody-HK2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HK2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HK2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for HK2. It may not necessarily be applicable to this product.
 NCBI GI #    39963174
 NCBI GeneID    3099
 NCBI Accession #    AAH64369.1 [Other Products]
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 UniProt Primary Accession #    P52789 [Other Products]
 UniProt Secondary Accession #    Q8WU87; Q9UN82; D6W5J2 [Other Products]
 UniProt Related Accession #    P52789 [Other Products]
 Molecular Weight    102,380 Da
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 NCBI Official Full Name    Hexokinase 2
 NCBI Official Synonym Full Names    hexokinase 2
 NCBI Official Symbol    HK2 [Similar Products]
 NCBI Official Synonym Symbols   
HKII; HXK2
[Similar Products]
 NCBI Protein Information    hexokinase-2; HK II; hexokinase type II; hexokinase-2, muscle; muscle form hexokinase
 UniProt Protein Name    Hexokinase-2
 UniProt Synonym Protein Names   
Hexokinase type II; HK II; Muscle form hexokinase
 Protein Family    Probable histidine kinase
 UniProt Gene Name    HK2 [Similar Products]
 UniProt Synonym Gene Names    HK II [Similar Products]
 UniProt Entry Name    HXK2_HUMAN
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 NCBI Summary for HK2    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]
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 UniProt Comments for HK2    HK2: a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). The predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase). Genetic variations of HK2 do not appear to contribute to NIDDM.

Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.7.1.1; Mitochondrial; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - fructose and mannose; Kinase, other; Carbohydrate Metabolism - galactose

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: mitochondrial outer membrane; membrane; cytosol

Molecular Function: hexokinase activity; mannokinase activity; fructokinase activity; glucokinase activity; ATP binding; glucose binding

Biological Process: lactation; apoptotic mitochondrial changes; glycolysis; hexose transport; glucose 6-phosphate metabolic process; carbohydrate phosphorylation; carbohydrate metabolic process; cell glucose homeostasis; glucose metabolic process; pathogenesis; regulation of glucose import; glucose transport; transmembrane transport
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 Research Articles on HK2    1. chronic inhibition of GSK-3 elicited a marked increase in brain-derived neurotrophic factor (BDNF) secretion, which in turn conferred resistance to mitochondrial dysfunction through subcellular re-distribution of HKII.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HK2 elisa kitPathways associated with HK2 elisa kit
 Reference Product  PubMed Publications
 GPI elisa kit  >4 publications with HK2 and GPI
 PFKM elisa kit  >2 publications with HK2 and PFKM
 PFKL elisa kit  >1 publications with HK2 and PFKL
 C12orf5 elisa kit  >1 publications with HK2 and C12orf5
 PFKP elisa kit  >1 publications with HK2 and PFKP
 Products by Pathway  Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Butirosin And Neomycin Biosynthesis Pathway antibodies  Butirosin And Neomycin Biosynthesis Pathway Diagram
 Butirosin And Neomycin Biosynthesis Pathway antibodies  Butirosin And Neomycin Biosynthesis Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
Diseases associated with HK2 elisa kitOrgans/Tissues associated with HK2 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >208 publications with HK2 and Neoplasms
 Kidney Diseases Antibodies  >41 publications with HK2 and Kidney Diseases
 Hyperplasia Antibodies  >39 publications with HK2 and Hyperplasia
 Fibrosis Antibodies  >27 publications with HK2 and Fibrosis
 Breast Neoplasms Antibodies  >21 publications with HK2 and Breast Neoplasms
 Death Antibodies  >20 publications with HK2 and Death
 Cardiovascular Diseases Antibodies  >14 publications with HK2 and Cardiovascular Diseases
 Drug Toxicity Antibodies  >12 publications with HK2 and Drug Toxicity
 Neoplasms, Experimental Antibodies  >10 publications with HK2 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >9 publications with HK2 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >237 publications with HK2 and Prostate
 Blood Antibodies  >125 publications with HK2 and Blood
 Kidney Antibodies  >97 publications with HK2 and Kidney
 Muscle Antibodies  >26 publications with HK2 and Muscle
 Liver Antibodies  >20 publications with HK2 and Liver
 Brain Antibodies  >19 publications with HK2 and Brain
 Heart Antibodies  >15 publications with HK2 and Heart
 Embryonic Tissue Antibodies  >14 publications with HK2 and Embryonic Tissue
 Bone Antibodies  >12 publications with HK2 and Bone
 Lung Antibodies  >10 publications with HK2 and Lung
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