NP_004097.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,667 Da
NCBI Official Full Name
high affinity immunoglobulin epsilon receptor subunit gamma
NCBI Official Synonym Full Names
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
NCBI Official Synonym Symbols
NCBI Protein Information
high affinity immunoglobulin epsilon receptor subunit gamma; fcRgamma; fceRI gamma; fc-epsilon RI-gamma; Fc receptor gamma-chain; immunoglobulin E receptor, high affinity, gamma chain
UniProt Protein Name
High affinity immunoglobulin epsilon receptor subunit gamma
UniProt Synonym Protein Names
Fc receptor gamma-chain; FcRgamma; Fc-epsilon RI-gamma; IgE Fc receptor subunit gamma; FceRI gamma
UniProt Synonym Gene Names
UniProt Entry Name
FCERG_HUMAN
NCBI Summary for FCER1G
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]
UniProt Comments for FCER1G
FCER1G: Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin. Belongs to the CD3Z/FCER1G family.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q23
Cellular Component: cell surface; integral to plasma membrane; Fc-epsilon receptor I complex; plasma membrane; external side of plasma membrane
Molecular Function: protein binding; IgG binding; IgE binding; IgE receptor activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; mast cell activation; positive regulation of interleukin-10 production; negative regulation of mast cell apoptosis; positive regulation of phagocytosis; antigen processing and presentation of exogenous peptide antigen via MHC class I; Fc receptor mediated stimulatory signaling pathway; integrin-mediated signaling pathway; neutrophil chemotaxis; platelet activation; positive regulation of type I hypersensitivity; positive regulation of interleukin-6 production; positive regulation of mast cell degranulation; positive regulation of type III hypersensitivity; positive regulation of tumor necrosis factor production; neutrophil activation during immune response; serotonin secretion by platelet; positive regulation of type IIa hypersensitivity; defense response to bacterium; innate immune response; immunoglobulin mediated immune response; positive regulation of mast cell cytokine production; blood coagulation; phagocytosis, engulfment; leukocyte migration
Research Articles on FCER1G
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Products associated with FCER1G elisa kit
Pathways associated with FCER1G elisa kit
Diseases associated with FCER1G elisa kit
Organs/Tissues associated with FCER1G elisa kit
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