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IFGF-23 elisa kit :: Canine Intact Fibroblast Growth Factor 23 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS754365
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Intact Fibroblast Growth Factor 23 (IFGF-23), ELISA Kit

★Popular Item★
 Also Known As   

Canine Intact Fibroblast Growth Factor 23 ELISA Kit

 Product Gene Name   

IFGF-23 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    605380
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 Species Reactivity    Canine
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 Specificity    This assay has high sensitivity and excellent specificity for detection of iFGF-23. No significant cross-reactivity or interference between iFGF-23 and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between iFGF-23 and all the analogues, therefore, cross reaction may still exist in some cases.
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Sensitivity    1.0 pg/mL.
 Intended Uses    This iFGF-23 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Canine iFGF-23. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IFGF-23 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IFGF-23 purchase    MBS754365 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Intact Fibroblast Growth Factor 23 (IFGF-23) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IFGF-23, with an estimated sensitivity of 1.0 pg/mL. The ELISA analytical biochemical technique of the MBS754365 kit is based on IFGF-23 antibody-IFGF-23 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IFGF-23 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IFGF-23. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for IFGF-23 elisa kit

   Princple of the assay: iFGF-23 ELISA kit applies the competitive enzyme immunoassay technique utilizing a monoclonal anti-iFGF-23 antibody and an iFGF-23-HRP conjugate. The assay sample and buffer are incubated together with iFGF-23-HRP conjugate in pre-coated plate for one hour. After the incubation period, the wells are decanted and washed five times. The wells are then incubated with a substrate for HRP enzyme. The product of the enzyme-substrate reaction forms a blue colored complex. Finally, a stop solution is added to stop the reaction, which will then turn the solution yellow. The intensity of color is measured spectrophotometrically at 450nm in a microplate reader. The intensity of the color is inversely proportional to the iFGF-23 concentration since iFGF-23 from samples and iFGF-23-HRP conjugate compete for the anti-iFGF-23 antibody binding site. Since the number of sites is limited, as more sites are occupied by iFGF-23 from the sample, fewer sites are left to bind iFGF-23-HRP conjugate. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The iFGF-23 concentration in each sample is interpolated from this standard curve.
 Product Categories/Family for IFGF-23 elisa kit    Cancer
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 Typical Testing Data/Standard Curve (for reference only) of IFGF-23 elisa kit    IFGF-23 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS754365. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IFGF-23. It may not necessarily be applicable to this product.
 NCBI GI #    9964292
 NCBI GeneID    8074
 NCBI Accession #    AAG09917.1 [Other Products]
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 UniProt Secondary Accession #    Q4V758 [Other Products]
 UniProt Related Accession #    Q9GZV9 [Other Products]
 Molecular Weight    27,954 Da
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 NCBI Official Full Name    FGF23
 NCBI Official Synonym Full Names    fibroblast growth factor 23
 NCBI Official Symbol    FGF23 [Similar Products]
 NCBI Official Synonym Symbols   
ADHR; FGFN; HYPF; HPDR2; PHPTC
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 23; phosphatonin; tumor-derived hypophosphatemia inducing factor
 UniProt Protein Name    Fibroblast growth factor 23
 UniProt Synonym Protein Names   
Phosphatonin; Tumor-derived hypophosphatemia-inducing factorCleaved into the following 2 chains:Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide
 UniProt Gene Name    FGF23 [Similar Products]
 UniProt Synonym Gene Names    HYPF; UNQ3027/PRO9828; FGF-23 [Similar Products]
 UniProt Entry Name    FGF23_HUMAN
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 NCBI Summary for IFGF-23    This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
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 UniProt Comments for IFGF-23    FGF23: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR). ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses. Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; type 1 fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; negative regulation of hormone secretion; phosphate metabolic process; negative regulation of bone mineralization; cellular phosphate ion homeostasis; insulin receptor signaling pathway; innate immune response; negative regulation of osteoblast differentiation; phosphate ion homeostasis; cell differentiation; vitamin D catabolic process

Disease: Hypophosphatemic Rickets, Autosomal Dominant
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 Research Articles on IFGF-23    1. High FGF-23 levels in hemodialysis patients may contribute to cognitive impairment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IFGF-23 elisa kitPathways associated with IFGF-23 elisa kit
 Reference Product  PubMed Publications
 PTH elisa kit  >256 publications with IFGF-23 and PTH
 PHEX elisa kit  >101 publications with IFGF-23 and PHEX
 FGFR1 elisa kit  >51 publications with IFGF-23 and FGFR1
 GALNT3 elisa kit  >45 publications with IFGF-23 and GALNT3
 MEPE elisa kit  >27 publications with IFGF-23 and MEPE
 FGFR3 elisa kit  >14 publications with IFGF-23 and FGFR3
 FGFR4 elisa kit  >11 publications with IFGF-23 and FGFR4
 FGFR2 elisa kit  >10 publications with IFGF-23 and FGFR2
 FGF1 elisa kit  >7 publications with IFGF-23 and FGF1
 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
Diseases associated with IFGF-23 elisa kitOrgans/Tissues associated with IFGF-23 elisa kit
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >419 publications with IFGF-23 and Kidney Diseases
 Rickets Antibodies  >264 publications with IFGF-23 and Rickets
 Phosphorus Metabolism Disorders Antibodies  >258 publications with IFGF-23 and Phosphorus Metabolism Disorders
 Renal Insufficiency Antibodies  >186 publications with IFGF-23 and Renal Insufficiency
 Hyperphosphatemia Antibodies  >151 publications with IFGF-23 and Hyperphosphatemia
 Calcinosis Antibodies  >110 publications with IFGF-23 and Calcinosis
 Hyperparathyroidism, Secondary Antibodies  >103 publications with IFGF-23 and Hyperparathyroidism, Secondary
 Hypertension Antibodies  >64 publications with IFGF-23 and Hypertension
 Hypophosphatemic Rickets, Autosomal Dominant Antibodies  >64 publications with IFGF-23 and Hypophosphatemic Rickets, Autosomal Dominant
 Hypertrophy Antibodies  >43 publications with IFGF-23 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >11 publications with IFGF-23 and Embryonic Tissue
 Testis Antibodies  >2 publications with IFGF-23 and Testis
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