CAA91227.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,330 Da
NCBI Official Full Name
interferon regulatory factor 3
NCBI Official Synonym Full Names
interferon regulatory factor 3
NCBI Official Synonym Symbols
NCBI Protein Information
interferon regulatory factor 3
UniProt Protein Name
Interferon regulatory factor 3
UniProt Synonym Gene Names
UniProt Entry Name
IRF3_HUMAN
NCBI Summary for IRF3
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for IRF3
IRF3: interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19q13.3-q13.4
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: DNA binding; identical protein binding; protein binding; protein homodimerization activity; transcription cofactor activity
Biological Process: apoptosis; cytokine and chemokine mediated signaling pathway; defense response to virus; innate immune response; interferon type I biosynthetic process; lipopolysaccharide-mediated signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of interferon type I production; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; response to DNA damage stimulus; response to exogenous dsRNA; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter; viral reproduction
Disease: Herpes Simplex Encephalitis, Susceptibility To, 7
Research Articles on IRF3
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Products associated with IRF3 elisa kit
Pathways associated with IRF3 elisa kit
Diseases associated with IRF3 elisa kit
Organs/Tissues associated with IRF3 elisa kit
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