NP_835258.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
LIM/homeobox protein Lhx3 isoform a
NCBI Official Synonym Full Names
LIM homeobox 3
NCBI Protein Information
LIM/homeobox protein Lhx3; LIM homeobox protein 3; LIM/homeodomain protein LHX3
UniProt Protein Name
LIM/homeobox protein Lhx3
UniProt Synonym Gene Names
UniProt Entry Name
LHX3_HUMAN
NCBI Summary for LHX3
This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
UniProt Comments for LHX3
LHX3: Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1. Defects in LHX3 are the cause of pituitary hormone deficiency combined type 3 (CPHD3); also known as combined pituitary hormone deficiency with rigid cervical spine or sensorineural deafness with pituitary dwarfism. CPHD is characterized by a complete deficit in all but one (adrenocorticotropin) anterior pituitary hormone and a rigid cervical spine leading to limited head rotation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: transcription factor complex; nucleus
Molecular Function: zinc ion binding; sequence-specific DNA binding
Biological Process: transcription from RNA polymerase II promoter; organ morphogenesis; pituitary gland development; positive regulation of transcription, DNA-dependent; spinal cord motor neuron cell fate specification; spinal cord association neuron differentiation; medial motor column neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; motor axon guidance; ventral spinal cord interneuron specification; inner ear development; negative regulation of apoptosis; lung development; placenta development
Disease: Pituitary Hormone Deficiency, Combined, 3
Research Articles on LHX3
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Products associated with LHX3 elisa kit
Diseases associated with LHX3 elisa kit
Disease Name |
Pubmed Publications |
Pituitary Hormone Deficiency, Combined, 2 Antibodies |
>17 publications with LHX3 and Pituitary Hormone Deficiency, Combined, 2 |
Congenital Abnormalities Antibodies |
>14 publications with LHX3 and Congenital Abnormalities |
Hearing Loss Antibodies |
>6 publications with LHX3 and Hearing Loss |
Disease Models, Animal Antibodies |
>3 publications with LHX3 and Disease Models, Animal |
Kidney Diseases Antibodies |
>2 publications with LHX3 and Kidney Diseases |
Cell Transformation, Neoplastic Antibodies |
>1 publications with LHX3 and Cell Transformation, Neoplastic |
Child Development Disorders, Pervasive Antibodies |
>1 publications with LHX3 and Child Development Disorders, Pervasive |
Hyperplasia Antibodies |
>1 publications with LHX3 and Hyperplasia |
Uremia Antibodies |
>1 publications with LHX3 and Uremia |
Learning Disorders Antibodies |
>1 publications with LHX3 and Learning Disorders |
Organs/Tissues associated with LHX3 elisa kit
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