NP_001002273.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
low affinity immunoglobulin gamma Fc region receptor II-b isoform 2
NCBI Official Synonym Full Names
Fc fragment of IgG, low affinity IIb, receptor (CD32)
NCBI Official Synonym Symbols
CD32; FCG2; CD32B; FCGR2; IGFR2 [Similar Products]
NCBI Protein Information
low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; fcRII-b; Fc gamma RIIb; fc-gamma-RIIb; fc-gamma RII-b; igG Fc receptor II-b; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32)
UniProt Protein Name
Low affinity immunoglobulin gamma Fc region receptor II-b
UniProt Synonym Protein Names
CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; CD_antigen: CD32
UniProt Synonym Gene Names
CD32; FCG2; IGFR2; IgG Fc receptor II-b; Fc-gamma-RIIb; FcRII-b [Similar Products]
UniProt Entry Name
FCG2B_HUMAN
NCBI Summary for FCGR2B
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt Comments for FCGR2B
FCGR2B: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.
Protein type: Membrane protein, integral; Cell surface; Oncoprotein
Chromosomal Location of Human Ortholog: 1q23
Cellular Component: plasma membrane; integral to membrane
Molecular Function: protein binding; IgG binding
Biological Process: regulation of immune response; viral reproduction; immune response; signal transduction
Disease: Systemic Lupus Erythematosus; Malaria, Susceptibility To
Research Articles on FCGR2B
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