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CA15-3 elisa kit :: Canine Mammary Carcinoma Marker/Carbohydrate Antigen15-3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS022063 CA15-3 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mammary Carcinoma Marker/Carbohydrate Antigen15-3 (CA15-3), ELISA Kit

★Popular Item★
 Also Known As   

Canine Mammary Carcinoma Marker/Carbohydrate Antigen15-3 ELISA Kit

 Product Gene Name   

CA15-3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    113720
 3D Structure    ModBase 3D Structure for P15941
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 Species Reactivity    Canine
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    undiluted original Canine body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    3.12U/ml-100U/mL
 Sensitivity    1.0U/mL
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CA15-3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CA15-3 purchase    MBS022063 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Mammary Carcinoma Marker/Carbohydrate Antigen15-3 (CA15-3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 3.12U/ml-100U/mL in biological research samples containing CA15-3, with an estimated sensitivity of 1.0U/mL. The ELISA analytical biochemical technique of the MBS022063 kit is based on CA15-3 antibody-CA15-3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CA15-3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CA15-3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as undiluted original Canine body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CA15-3 elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of CA153 (hereafter termed "analyte") in undiluted original Canine body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS022063. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CA15-3. It may not necessarily be applicable to this product.
 NCBI GI #    296439295
 NCBI GeneID    4582
 NCBI Accession #    P15941.3 [Other Products]
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 UniProt Primary Accession #    P15941 [Other Products]
 UniProt Secondary Accession #    P13931; P15942; P17626; A5YRV1; A6ZID9; A6ZIE0; B1AVQ8; B1AVR0; B6ECA1; E7ESE5; E7EUG9 [Other Products]
 UniProt Related Accession #    P15941 [Other Products]
 Molecular Weight    122,102 Da
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 NCBI Official Full Name    Mucin-1
 NCBI Official Synonym Full Names    mucin 1, cell surface associated
 NCBI Official Symbol    MUC1 [Similar Products]
 NCBI Official Synonym Symbols   
EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC
[Similar Products]
 NCBI Protein Information    mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen
 UniProt Protein Name    Mucin-1
 UniProt Synonym Protein Names   
Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial mucin; PEM; Tumor-associated epithelial membrane antigen; EMA; Tumor-associated mucin; CD_antigen: CD227Cleaved into the following 2 chains:Mucin-1 subunit alpha; MUC1-NT; MUC1-alpha; Mucin-1 subunit beta; MUC1-betaAlternative name(s):MUC1-CT
 UniProt Gene Name    MUC1 [Similar Products]
 UniProt Synonym Gene Names    PUM; MUC-1; CA 15-3; KL-6; PUM; PEM; EMA; MUC1-NT; MUC1-alpha; MUC1-beta [Similar Products]
 UniProt Entry Name    MUC1_HUMAN
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 NCBI Summary for CA15-3    This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
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 UniProt Comments for CA15-3    MUC1: a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. Plays a role in adhesion and cell-cell interactions, metastasis and signaling. May provide a protective layer on epithelial surfaces. Direct or indirect interaction with actin cytoskeleton. Its cytoplasmic tail (MUC1CT) is involved in several signaling pathways, including those involving Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. MUC1CT also forms complexes with transcription factors, and then translocates to the nucleus by an unknown mechanism, where it is believed to influence the transcription of their target genes. MUC1CT has also been proposed to localize to mitochondrial membranes under conditions of genotoxic stress, where it attenuates the apoptotic pathway in response and confers resistance to apoptosis-inducing drugs. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Nine alternatively spliced isoforms have been described. Isoforms 5 and 9 are secreted. Isoform 7, expressed only in tumor cells, is a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein.

Protein type: Cell adhesion; Actin-binding; Tumor suppressor; Membrane protein, integral; Nuclear receptor co-regulator; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular space; cell surface; integral to plasma membrane; Golgi lumen; apical plasma membrane; cytoplasm; nuclear chromatin; vesicle

Molecular Function: protein binding; p53 binding; transcription cofactor activity

Biological Process: protein amino acid O-linked glycosylation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; cellular protein metabolic process; regulation of transcription from RNA polymerase II promoter in response to stress; O-glycan processing; post-translational protein modification; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Disease: Medullary Cystic Kidney Disease 1
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 Research Articles on CA15-3    1. GCNT1 is over-expressed in prostate cancer and is associated with higher levels of core 2 O-sLe(x) in PSA, PAP and MUC1 proteins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CA15-3 elisa kitDiseases associated with CA15-3 elisa kit
 Products by Pathway  Pathway Diagram
 IL-7 Signaling Pathway antibodies  IL-7 Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 O-linked Glycosylation Of Mucins Pathway antibodies  O-linked Glycosylation Of Mucins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Termination Of O-glycan Biosynthesis Pathway antibodies  Termination Of O-glycan Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1906 publications with CA15-3 and Neoplasms
 Carcinoma Antibodies  >1131 publications with CA15-3 and Carcinoma
 Breast Neoplasms Antibodies  >592 publications with CA15-3 and Breast Neoplasms
 Lung Diseases Antibodies  >437 publications with CA15-3 and Lung Diseases
 Lung Neoplasms Antibodies  >196 publications with CA15-3 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >169 publications with CA15-3 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >163 publications with CA15-3 and Ovarian Neoplasms
 Disease Models, Animal Antibodies  >159 publications with CA15-3 and Disease Models, Animal
 Pneumonia Antibodies  >131 publications with CA15-3 and Pneumonia
 Inflammation Antibodies  >113 publications with CA15-3 and Inflammation
Organs/Tissues associated with CA15-3 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >506 publications with CA15-3 and Lung
 Stomach Antibodies  >204 publications with CA15-3 and Stomach
 Pancreas Antibodies  >198 publications with CA15-3 and Pancreas
 Liver Antibodies  >176 publications with CA15-3 and Liver
 Intestine Antibodies  >149 publications with CA15-3 and Intestine
 Prostate Antibodies  >97 publications with CA15-3 and Prostate
 Eye Antibodies  >97 publications with CA15-3 and Eye
 Kidney Antibodies  >91 publications with CA15-3 and Kidney
 Uterus Antibodies  >75 publications with CA15-3 and Uterus
 Ovary Antibodies  >56 publications with CA15-3 and Ovary
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