NP_005111.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
242,953 Da
NCBI Official Full Name
mediator of RNA polymerase II transcription subunit 12
NCBI Official Synonym Full Names
mediator complex subunit 12
NCBI Official Synonym Symbols
OKS; FGS1; HOPA; OPA1; OHDOX; ARC240; CAGH45; MED12S; TNRC11; TRAP230 [Similar Products]
NCBI Protein Information
mediator of RNA polymerase II transcription subunit 12; CAG repeat protein 45; human opposite paired; OPA-containing protein; putative mediator subunit 12; activator-recruited cofactor 240 kDa component; trinucleotide repeat-containing gene 11 protein; thyroid hormone receptor-associated protein, 230 kDa subunit; mediator of RNA polymerase II transcription, subunit 12 homolog; thyroid hormone receptor-associated protein complex 230 kDa component; trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)
UniProt Protein Name
Mediator of RNA polymerase II transcription subunit 12
UniProt Synonym Protein Names
Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein
UniProt Synonym Gene Names
ARC240; CAGH45; HOPA; KIAA0192; TNRC11; TRAP230; ARC240; Trap230 [Similar Products]
UniProt Entry Name
MED12_HUMAN
NCBI Summary for MED12
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
UniProt Comments for MED12
MED12: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Also interacts with CTNNB1 and GLI3. Ubiquitous. Belongs to the Mediator complex subunit 12 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: Xq13
Cellular Component: nucleoplasm; centrosome; membrane; nucleolus; Srb-mediator complex; nucleus
Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; vitamin D receptor binding; transcription coactivator activity; beta-catenin binding; transcription cofactor activity; chromatin binding; thyroid hormone receptor binding; receptor activity
Biological Process: steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; Schwann cell development; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; heart development; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; neural tube closure; stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; gene expression; Wnt receptor signaling pathway through beta-catenin; oligodendrocyte development
Disease: Ohdo Syndrome, X-linked; Opitz-kaveggia Syndrome; Lujan-fryns Syndrome
Research Articles on MED12
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Products associated with MED12 elisa kit
Pathways associated with MED12 elisa kit
Diseases associated with MED12 elisa kit
Organs/Tissues associated with MED12 elisa kit
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