NP_005112.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
239,297 Da
NCBI Official Full Name
mediator of RNA polymerase II transcription subunit 13
NCBI Official Synonym Full Names
mediator complex subunit 13
NCBI Official Synonym Symbols
ARC250; THRAP1; DRIP250; HSPC221; TRAP240 [Similar Products]
NCBI Protein Information
mediator of RNA polymerase II transcription subunit 13; thyroid hormone receptor associated protein 1; thyroid hormone receptor-associated protein 1; activator-recruited cofactor 250 kDa component; thyroid hormone receptor-associated protein, 240 kDa subunit; mediator of RNA polymerase II transcription, subunit 13 homolog; vitamin D3 receptor-interacting protein complex component DRIP250; thyroid hormone receptor-associated protein complex 240 kDa component; thyroid hormone receptor-associated protein complex component TRAP240
UniProt Protein Name
Mediator of RNA polymerase II transcription subunit 13
UniProt Synonym Protein Names
Activator-recruited cofactor 250 kDa component; ARC250; Mediator complex subunit 13; Thyroid hormone receptor-associated protein 1; Thyroid hormone receptor-associated protein complex 240 kDa component; Trap240; Vitamin D3 receptor-interacting protein complex component DRIP250; DRIP250
UniProt Synonym Gene Names
UniProt Entry Name
MED13_HUMAN
NCBI Summary for MED13
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]
UniProt Comments for MED13
Trap240: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 13 family.
Protein type: Nuclear receptor
Chromosomal Location of Human Ortholog: 17q22-q23
Cellular Component: nucleoplasm; membrane; Srb-mediator complex; nucleus
Molecular Function: ligand-dependent nuclear receptor transcription coactivator activity; vitamin D receptor binding; transcription coactivator activity; transcription cofactor activity; receptor activity; thyroid hormone receptor binding
Biological Process: steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter
Research Articles on MED13
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Products associated with MED13 elisa kit
Pathways associated with MED13 elisa kit
Diseases associated with MED13 elisa kit
Organs/Tissues associated with MED13 elisa kit
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