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MC elisa kit :: Canine Melanocyte Antibody ELISA Kit

Scan QR to view Datasheet Catalog #    MBS017104 MC elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Melanocyte Antibody (MC), ELISA Kit

 Also Known As   

Canine Melanocyte Antibody ELISA Kit

 Product Gene Name   

MC elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    155550
 3D Structure    ModBase 3D Structure for P40967
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 Species Reactivity    Canine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for MC purchase    MBS017104 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Melanocyte Antibody (MC) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MC. The ELISA analytical biochemical technique of the MBS017104 kit is based on MC antibody-MC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MC. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for MC. It may not necessarily be applicable to this product.
 NCBI GI #    2507099
 NCBI GeneID    6490
 NCBI Accession #    P40967.2 [Other Products]
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 UniProt Primary Accession #    P40967 [Other Products]
 UniProt Secondary Accession #    Q12763; Q14448; Q14817; Q16565; B3KS57; B7Z6D7 [Other Products]
 UniProt Related Accession #    P40967 [Other Products]
 Molecular Weight    70,255 Da
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 NCBI Official Full Name    Melanocyte protein PMEL
 NCBI Official Synonym Full Names    premelanosome protein
 NCBI Official Symbol    PMEL [Similar Products]
 NCBI Official Synonym Symbols   
P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E
[Similar Products]
 NCBI Protein Information    melanocyte protein PMEL; melanocyte protein mel 17; silver, mouse, homolog of; melanocyte protein Pmel 17; melanosomal matrix protein17; silver locus protein homolog; melanoma-associated ME20 antigen; melanocytes lineage-specific antigen GP100
 UniProt Protein Name    Melanocyte protein PMEL
 UniProt Synonym Protein Names   
ME20-M; ME20M; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; P1; P100; Premelanosome protein; Silver locus protein homologCleaved into the following 2 chains:M-alpha; Alternative name(s):; 95 kDa melanocyte-specific secreted glycoprotein; P26; Secreted melanoma-associated ME20 antigen
 UniProt Gene Name    PMEL [Similar Products]
 UniProt Synonym Gene Names    D12S53E; PMEL17; SILV; ME20M; ME20-S; ME20S [Similar Products]
 UniProt Entry Name    PMEL_HUMAN
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 NCBI Summary for MC    This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
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 UniProt Comments for MC    SILV: Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. Belongs to the PMEL/NMB family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 12q13-q14

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; integral to membrane; melanosome; plasma membrane; extracellular region

Molecular Function: protein binding

Biological Process: melanin biosynthetic process; melanosome organization and biogenesis
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 Research Articles on MC    1. SIL-TAL1 rearrangement identifies a distinct subtype with inferior outcome which could allow for individual therapeutic stratification for T-ALL patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with MC elisa kitOrgans/Tissues associated with MC elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >383 publications with MC and Neoplasms
 Skin Diseases Antibodies  >114 publications with MC and Skin Diseases
 Disease Models, Animal Antibodies  >81 publications with MC and Disease Models, Animal
 Necrosis Antibodies  >17 publications with MC and Necrosis
 Nervous System Diseases Antibodies  >16 publications with MC and Nervous System Diseases
 Lung Diseases Antibodies  >14 publications with MC and Lung Diseases
 Brain Diseases Antibodies  >9 publications with MC and Brain Diseases
 Leukopenia Antibodies  >6 publications with MC and Leukopenia
 Pain Antibodies  >5 publications with MC and Pain
 Kidney Diseases Antibodies  >5 publications with MC and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >126 publications with MC and Skin
 Lung Antibodies  >22 publications with MC and Lung
 Eye Antibodies  >19 publications with MC and Eye
 Spleen Antibodies  >18 publications with MC and Spleen
 Brain Antibodies  >15 publications with MC and Brain
 Kidney Antibodies  >12 publications with MC and Kidney
 Bone Antibodies  >10 publications with MC and Bone
 Testis Antibodies  >8 publications with MC and Testis
 Liver Antibodies  >8 publications with MC and Liver
 Muscle Antibodies  >7 publications with MC and Muscle
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