NP_443748.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,052 Da
NCBI Official Full Name
melanophilin
NCBI Official Synonym Full Names
melanophilin
NCBI Official Synonym Symbols
ln; l1Rk3; Slac-2a; AW228792; D1Wsu84e; l(1)-3Rk; 2210418F23Rik; 5031433I09Rik [Similar Products]
NCBI Protein Information
melanophilin
UniProt Protein Name
Melanophilin
UniProt Synonym Protein Names
Exophilin-3; Leaden protein; Slp homolog lacking C2 domains a; SlaC2-a; Synaptotagmin-like protein 2a
UniProt Synonym Gene Names
UniProt Entry Name
MELPH_MOUSE
UniProt Comments for MLPH
MLPH: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3). GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Cellular Component: actin cytoskeleton; cortical actin cytoskeleton; dendrite; melanosome; microtubule organizing center; perinuclear region of cytoplasm; stress fiber
Molecular Function: actin binding; metal ion binding; microtubule plus-end binding; myosin binding; myosin V binding; protein binding; Rab GTPase binding
Biological Process: intracellular protein transport; melanocyte differentiation; melanosome localization; pigmentation; protein targeting
Research Articles on MLPH
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Products associated with MLPH elisa kit
Pathways associated with MLPH elisa kit
Diseases associated with MLPH elisa kit
Organs/Tissues associated with MLPH elisa kit
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