NP_733820.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,015 Da
NCBI Official Full Name
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 isoform 2
NCBI Official Synonym Full Names
nicotinamide nucleotide adenylyltransferase 2
NCBI Protein Information
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
UniProt Protein Name
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
UniProt Synonym Protein Names
Nicotinamide mononucleotide adenylyltransferase 2; NMN adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2; NaMN adenylyltransferase 2
UniProt Synonym Gene Names
C1orf15; KIAA0479; NMN/NaMN adenylyltransferase 2; NMN adenylyltransferase 2; NaMN adenylyltransferase 2 [Similar Products]
UniProt Entry Name
NMNA2_HUMAN
NCBI Summary for NMNAT2
This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for NMNAT2
NMNAT2: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Belongs to the eukaryotic NMN adenylyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.7.1; EC 2.7.7.18; Transferase
Chromosomal Location of Human Ortholog: 1q25
Cellular Component: Golgi apparatus; Golgi membrane; late endosome; synapse; trans-Golgi network
Molecular Function: ATP binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity
Biological Process: NAD biosynthetic process; NAD metabolic process; vitamin metabolic process; water-soluble vitamin metabolic process
Research Articles on NMNAT2
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Pathways associated with NMNAT2 elisa kit
Diseases associated with NMNAT2 elisa kit
Organs/Tissues associated with NMNAT2 elisa kit
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