NP_001186566.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,957 Da
NCBI Official Full Name
pituitary adenylate cyclase-activating polypeptide type I receptor isoform 4
NCBI Official Synonym Full Names
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
NCBI Protein Information
pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP receptor 1; PACAP type I receptor; PACAP-R1; pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop
UniProt Protein Name
Pituitary adenylate cyclase-activating polypeptide type I receptor
UniProt Synonym Gene Names
UniProt Entry Name
PACR_HUMAN
NCBI Summary for PACAP-38
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
UniProt Comments for PACAP-38
ADCYAP1R1: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. Belongs to the G-protein coupled receptor 2 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 2; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 7p14
Cellular Component: neuron projection; tight junction; cell surface; rough endoplasmic reticulum; integral to plasma membrane; plasma membrane; caveola; endosome; receptor complex
Molecular Function: neuropeptide binding; ADP-ribosylation factor binding; vasoactive intestinal polypeptide receptor activity; protein binding; receptor activity; adenylate cyclase binding
Biological Process: response to drug; development of primary female sexual characteristics; G-protein coupled receptor protein signaling pathway; cAMP-mediated signaling; response to ethanol; cell surface receptor linked signal transduction; nerve growth factor receptor signaling pathway; phospholipase C activation; adenylate cyclase activation; spermatogenesis; cell differentiation; multicellular organismal response to stress; transmembrane receptor protein tyrosine kinase signaling pathway; response to estradiol stimulus
Research Articles on PACAP-38
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Products associated with PACAP-38 elisa kit
Pathways associated with PACAP-38 elisa kit
Diseases associated with PACAP-38 elisa kit
Organs/Tissues associated with PACAP-38 elisa kit
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