NP_002790.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,965 Da
NCBI Official Full Name
proteasome subunit beta type-7 proprotein
NCBI Official Synonym Full Names
proteasome (prosome, macropain) subunit, beta type, 7
NCBI Official Synonym Symbols
NCBI Protein Information
proteasome subunit beta type-7; macropain chain Z; proteasome subunit Z; proteasome subunit alpha; proteasome catalytic subunit 2; multicatalytic endopeptidase complex chain Z
UniProt Protein Name
Proteasome subunit beta type-7
UniProt Synonym Protein Names
Macropain chain Z; Multicatalytic endopeptidase complex chain Z; Proteasome subunit Z
UniProt Synonym Gene Names
UniProt Entry Name
PSB7_HUMAN
NCBI Summary for PSMB7
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]
UniProt Comments for PSMB7
PSMB7: a proteasomal protein of the T1B peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. Not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).
Protein type: EC 3.4.25.1; Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 9q34.11-q34.12
Cellular Component: proteasome complex; nucleoplasm; proteasome core complex; cytoplasm; nucleus; cytosol
Molecular Function: threonine endopeptidase activity; protein binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Research Articles on PSMB7
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Products associated with PSMB7 elisa kit
Pathways associated with PSMB7 elisa kit
Diseases associated with PSMB7 elisa kit
Organs/Tissues associated with PSMB7 elisa kit
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