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ATP2A2 elisa kit :: Canine Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7215782 ATP2A2 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit

 Also Known As   

Canine Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) ELISA Kit

 Product Gene Name   

ATP2A2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 124200
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 Species Reactivity    Canine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ATP2A2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ATP2A2 purchase    MBS7215782 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ATP2A2. The ELISA analytical biochemical technique of the MBS7215782 kit is based on ATP2A2 antibody-ATP2A2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ATP2A2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ATP2A2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for ATP2A2 elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for ATP2A2. It may not necessarily be applicable to this product.
 NCBI GI #    24638454
 NCBI GeneID    488
 NCBI Accession #    NP_733765.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_170665.3 [Other Products]
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 UniProt Secondary Accession #    P16614; Q86VJ2; A6NDN7; B4DF05 [Other Products]
 UniProt Related Accession #    P16615 [Other Products]
 Molecular Weight    109,734 Da
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 NCBI Official Full Name    sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b
 NCBI Official Synonym Full Names    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
 NCBI Official Symbol    ATP2A2 [Similar Products]
 NCBI Official Synonym Symbols   
DD; DAR; ATP2B; SERCA2
[Similar Products]
 NCBI Protein Information    sarcoplasmic/endoplasmic reticulum calcium ATPase 2; calcium pump 2; SR Ca(2+)-ATPase 2; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
 UniProt Protein Name    Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
 UniProt Synonym Protein Names   
Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
 Protein Family    Sarcoplasmic/endoplasmic reticulum calcium ATPase
 UniProt Gene Name    ATP2A2 [Similar Products]
 UniProt Synonym Gene Names    ATP2B; SERCA2; SR Ca(2+)-ATPase 2 [Similar Products]
 UniProt Entry Name    AT2A2_HUMAN
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 NCBI Summary for ATP2A2    This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]
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 UniProt Comments for ATP2A2    SERCA2: an intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. Possesses a Ca(2+)-ATPase activity. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Two alternatively spliced isoforms have been described.

Protein type: Endoplasmic reticulum; Transporter, ion channel; Membrane protein, integral; Transporter; Cell adhesion; EC 3.6.3.8; Hydrolase; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; sarcoplasmic reticulum; membrane; endoplasmic reticulum; integral to plasma membrane

Molecular Function: protein C-terminus binding; protein binding; enzyme binding; calcium-transporting ATPase activity; metal ion binding; calcium ion binding; ATP binding

Biological Process: cellular calcium ion homeostasis; ER-nuclear signaling pathway; epidermis development; endoplasmic reticulum calcium ion homeostasis; negative regulation of heart contraction; metabolic process; elevation of endoplasmic reticulum calcium ion concentration; positive regulation of heart rate; blood coagulation; cell adhesion; transmembrane transport; regulation of the force of heart contraction

Disease: Acrokeratosis Verruciformis; Darier-white Disease
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 Research Articles on ATP2A2    1. Exposure of normal keratinocytes to the SERCA2 inhibitor thapsigargin recapitulated these abnormalities, supporting the role of loss of SERCA2 function in impaired desmosome and adherens junction formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ATP2A2 elisa kitPathways associated with ATP2A2 elisa kit
 Reference Product  PubMed Publications
 PLN elisa kit  >18 publications with ATP2A2 and PLN
 SP1 elisa kit  >7 publications with ATP2A2 and SP1
 HAX1 elisa kit  >2 publications with ATP2A2 and HAX1
 SLN elisa kit  >2 publications with ATP2A2 and SLN
 TFB2M elisa kit  >1 publications with ATP2A2 and TFB2M
 IL6 elisa kit  >1 publications with ATP2A2 and IL6
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
Diseases associated with ATP2A2 elisa kitOrgans/Tissues associated with ATP2A2 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >203 publications with ATP2A2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >191 publications with ATP2A2 and Heart Diseases
 Darier Disease Antibodies  >120 publications with ATP2A2 and Darier Disease
 Heart Failure Antibodies  >114 publications with ATP2A2 and Heart Failure
 Hypertrophy Antibodies  >84 publications with ATP2A2 and Hypertrophy
 Disease Models, Animal Antibodies  >77 publications with ATP2A2 and Disease Models, Animal
 Cardiomegaly Antibodies  >57 publications with ATP2A2 and Cardiomegaly
 Cardiomyopathies Antibodies  >53 publications with ATP2A2 and Cardiomyopathies
 Ventricular Dysfunction, Left Antibodies  >51 publications with ATP2A2 and Ventricular Dysfunction, Left
 Myocardial Infarction Antibodies  >31 publications with ATP2A2 and Myocardial Infarction
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >298 publications with ATP2A2 and Muscle
 Heart Antibodies  >287 publications with ATP2A2 and Heart
 Blood Antibodies  >85 publications with ATP2A2 and Blood
 Skin Antibodies  >76 publications with ATP2A2 and Skin
 Vascular Antibodies  >42 publications with ATP2A2 and Vascular
 Brain Antibodies  >25 publications with ATP2A2 and Brain
 Lung Antibodies  >15 publications with ATP2A2 and Lung
 Thyroid Antibodies  >13 publications with ATP2A2 and Thyroid
 Embryonic Tissue Antibodies  >12 publications with ATP2A2 and Embryonic Tissue
 Pancreas Antibodies  >11 publications with ATP2A2 and Pancreas
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