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SMAC elisa kit :: Canine Second Mitochondrial-Derived Activator of Caspase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS004989 SMAC elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Second Mitochondrial-Derived Activator of Caspase (SMAC), ELISA Kit

 Also Known As   

Canine Second Mitochondrial-Derived Activator of Caspase ELISA Kit

 Product Gene Name   

SMAC elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 12; NC_000012.11 (122692209..122712068, complement). Location: 12q24.31
 OMIM    605219
 3D Structure    ModBase 3D Structure for Q9NR28
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 Species Reactivity    Canine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SMAC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SMAC purchase    MBS004989 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Second Mitochondrial-Derived Activator of Caspase (SMAC) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SMAC. The ELISA analytical biochemical technique of the MBS004989 kit is based on SMAC antibody-SMAC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SMAC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SMAC. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SMAC. It may not necessarily be applicable to this product.
 NCBI GI #    9454219
 NCBI GeneID    56616
 NCBI Accession #    AAF87716.1 [Other Products]
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 UniProt Primary Accession #    Q9NR28 [Other Products]
 UniProt Secondary Accession #    Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; B2RDQ0 [Other Products]
 UniProt Related Accession #    Q9NR28 [Other Products]
 Molecular Weight    27,131 Da
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 NCBI Official Full Name    Smac
 NCBI Official Synonym Full Names    diablo, IAP-binding mitochondrial protein
 NCBI Official Symbol    DIABLO [Similar Products]
 NCBI Official Synonym Symbols   
SMAC; DFNA64
[Similar Products]
 NCBI Protein Information    diablo homolog, mitochondrial; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase
 UniProt Protein Name    Diablo homolog, mitochondrial
 UniProt Synonym Protein Names   
Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase
 UniProt Gene Name    DIABLO [Similar Products]
 UniProt Synonym Gene Names    SMAC; Smac [Similar Products]
 UniProt Entry Name    DBLOH_HUMAN
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 NCBI Summary for SMAC    This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
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 UniProt Comments for SMAC    DIABLO: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. Homodimer. Interacts with NGFRAP1/BEX3. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Interacts with the monomeric and dimeric form of BIRC5/survivin. Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Mitochondrial

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: internal side of plasma membrane; mitochondrion; mitochondrial intermembrane space; cytosol

Molecular Function: protein binding

Biological Process: caspase activation; neuron apoptosis; induction of apoptosis via death domain receptors; positive regulation of apoptosis; apoptosis; caspase activation via cytochrome c; induction of apoptosis by oxidative stress

Disease: Deafness, Autosomal Dominant 64
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 Research Articles on SMAC    1. Expressions of SMAC/DIABLO and survivin were significantly reciprocal in breast cancer and benign tumor tissues.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SMAC elisa kitPathways associated with SMAC elisa kit
 Reference Product  PubMed Publications
 CASP3 elisa kit  >313 publications with SMAC and CASP3
 XIAP elisa kit  >283 publications with SMAC and XIAP
 CASP9 elisa kit  >240 publications with SMAC and CASP9
 BIRC5 elisa kit  >54 publications with SMAC and BIRC5
 BIRC2 elisa kit  >14 publications with SMAC and BIRC2
 TRAF2 elisa kit  >13 publications with SMAC and TRAF2
 BIRC7 elisa kit  >11 publications with SMAC and BIRC7
 BIRC3 elisa kit  >11 publications with SMAC and BIRC3
 BIRC6 elisa kit  >6 publications with SMAC and BIRC6
 UBC elisa kit  >3 publications with SMAC and UBC
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Apoptotic Factor-mediated Response Pathway antibodies  Apoptotic Factor-mediated Response Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Intrinsic Pathway For Apoptosis antibodies  Intrinsic Pathway For Apoptosis Diagram
 Release Of Apoptotic Factors From The Mitochondria Pathway antibodies  Release Of Apoptotic Factors From The Mitochondria Pathway Diagram
 SMAC Binds To IAPs Pathway antibodies  SMAC Binds To IAPs Pathway Diagram
 SMAC-mediated Apoptotic Response Pathway antibodies  SMAC-mediated Apoptotic Response Pathway Diagram
 SMAC-mediated Dissociation Of IAP:caspase Complexes Pathway antibodies  SMAC-mediated Dissociation Of IAP:caspase Complexes Pathway Diagram
Diseases associated with SMAC elisa kitOrgans/Tissues associated with SMAC elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >392 publications with SMAC and Neoplasms
 Necrosis Antibodies  >150 publications with SMAC and Necrosis
 Leukemia Antibodies  >89 publications with SMAC and Leukemia
 Brain Diseases Antibodies  >49 publications with SMAC and Brain Diseases
 Drug Toxicity Antibodies  >49 publications with SMAC and Drug Toxicity
 Lung Diseases Antibodies  >37 publications with SMAC and Lung Diseases
 Lung Neoplasms Antibodies  >35 publications with SMAC and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >32 publications with SMAC and Neoplasms, Experimental
 Liver Diseases Antibodies  >32 publications with SMAC and Liver Diseases
 Breast Neoplasms Antibodies  >29 publications with SMAC and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >83 publications with SMAC and Blood
 Brain Antibodies  >79 publications with SMAC and Brain
 Liver Antibodies  >55 publications with SMAC and Liver
 Lung Antibodies  >48 publications with SMAC and Lung
 Muscle Antibodies  >41 publications with SMAC and Muscle
 Heart Antibodies  >33 publications with SMAC and Heart
 Prostate Antibodies  >32 publications with SMAC and Prostate
 Nerve Antibodies  >27 publications with SMAC and Nerve
 Kidney Antibodies  >26 publications with SMAC and Kidney
 Vascular Antibodies  >18 publications with SMAC and Vascular
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