NP_001630.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
25,387 Da
NCBI Official Full Name
serum amyloid P-component
NCBI Official Synonym Full Names
amyloid P component, serum
NCBI Official Synonym Symbols
NCBI Protein Information
serum amyloid P-component; pentaxin-related; 9.5S alpha-1-glycoprotein
UniProt Protein Name
Serum amyloid P-component
UniProt Synonym Protein Names
9.5S alpha-1-glycoprotein
UniProt Synonym Gene Names
UniProt Entry Name
SAMP_HUMAN
NCBI Summary for SAP
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
UniProt Comments for SAP
APCS: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. Belongs to the pentaxin family.
Protein type: Secreted, signal peptide; Chaperone; Secreted
Chromosomal Location of Human Ortholog: 1q21-q23
Cellular Component: extracellular matrix; extracellular space; protein complex; extracellular region; nucleus
Molecular Function: complement component C1q binding; unfolded protein binding; virion binding; calcium ion binding; carbohydrate binding
Biological Process: protein folding; negative regulation of virion penetration into host cell; negative regulation of acute inflammatory response; acute-phase response; innate immune response; negative regulation of monocyte differentiation; chaperone-mediated protein complex assembly; negative regulation of viral reproduction
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Products associated with SAP elisa kit
Pathways associated with SAP elisa kit
Diseases associated with SAP elisa kit
Organs/Tissues associated with SAP elisa kit
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