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SOCS3 elisa kit :: Canine Suppressors of Cytokine Signaling 3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS011380 SOCS3 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Suppressors of Cytokine Signaling 3 (SOCS3), ELISA Kit

 Also Known As   

Canine Suppressors of Cytokine Signaling 3 ELISA Kit

 Product Gene Name   

SOCS3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 17; NC_000017.10 (76352859..76356158, complement). Location: 17q25.3
 OMIM    604176
 3D Structure    ModBase 3D Structure for O14543
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 Species Reactivity    Canine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SOCS3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SOCS3 purchase    MBS011380 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Suppressors of Cytokine Signaling 3 (SOCS3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SOCS3. The ELISA analytical biochemical technique of the MBS011380 kit is based on SOCS3 antibody-SOCS3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SOCS3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SOCS3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SOCS3. It may not necessarily be applicable to this product.
 NCBI GI #    45439352
 NCBI GeneID    9021
 NCBI Accession #    NP_003946.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003955.4 [Other Products]
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 UniProt Primary Accession #    O14543 [Other Products]
 UniProt Secondary Accession #    O14509 [Other Products]
 UniProt Related Accession #    O14543 [Other Products]
 Molecular Weight    24,770 Da
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 NCBI Official Full Name    suppressor of cytokine signaling 3
 NCBI Official Synonym Full Names    suppressor of cytokine signaling 3
 NCBI Official Symbol    SOCS3 [Similar Products]
 NCBI Official Synonym Symbols   
CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3
[Similar Products]
 NCBI Protein Information    suppressor of cytokine signaling 3; STAT-induced STAT inhibitor 3; cytokine-inducible SH2 protein 3
 UniProt Protein Name    Suppressor of cytokine signaling 3
 UniProt Synonym Protein Names   
Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3
 Protein Family    Suppressor of cytokine signaling
 UniProt Gene Name    SOCS3 [Similar Products]
 UniProt Synonym Gene Names    CIS3; SSI3; SOCS-3; CIS-3; SSI-3 [Similar Products]
 UniProt Entry Name    SOCS3_HUMAN
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 NCBI Summary for SOCS3    This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SOCS3    SOCS3: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST. Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilizes SOCS3 protein. Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with CUL2. Interacts with FGFR3. Interacts with INSR. Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; protein kinase inhibitor activity

Biological Process: regulation of growth; negative regulation of inflammatory response; cytokine and chemokine mediated signaling pathway; protein ubiquitination; negative regulation of protein kinase activity; negative regulation of insulin receptor signaling pathway; positive regulation of cell differentiation; JAK-STAT cascade; negative regulation of JAK-STAT cascade; negative regulation of apoptosis

Disease: Dermatitis, Atopic, 4
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 Research Articles on SOCS3    1. results suggested that there is no marked association between SOCS3 gene promoter region polymorphisms and the risk of developing metastatic colorectal cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SOCS3 elisa kitPathways associated with SOCS3 elisa kit
 Reference Product  PubMed Publications
 STAT3 elisa kit  >604 publications with SOCS3 and STAT3
 STAT1 elisa kit  >201 publications with SOCS3 and STAT1
 JAK2 elisa kit  >159 publications with SOCS3 and JAK2
 JAK1 elisa kit  >61 publications with SOCS3 and JAK1
 IL6 elisa kit  >38 publications with SOCS3 and IL6
 PTPN11 elisa kit  >27 publications with SOCS3 and PTPN11
 JAK3 elisa kit  >19 publications with SOCS3 and JAK3
 INSR elisa kit  >4 publications with SOCS3 and INSR
 LEPR elisa kit  >3 publications with SOCS3 and LEPR
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
Diseases associated with SOCS3 elisa kitOrgans/Tissues associated with SOCS3 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >351 publications with SOCS3 and Inflammation
 Neoplasms Antibodies  >208 publications with SOCS3 and Neoplasms
 Necrosis Antibodies  >192 publications with SOCS3 and Necrosis
 Disease Models, Animal Antibodies  >111 publications with SOCS3 and Disease Models, Animal
 Liver Diseases Antibodies  >101 publications with SOCS3 and Liver Diseases
 Nervous System Diseases Antibodies  >88 publications with SOCS3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >68 publications with SOCS3 and Cardiovascular Diseases
 Hepatitis Antibodies  >64 publications with SOCS3 and Hepatitis
 Carcinoma, Hepatocellular Antibodies  >37 publications with SOCS3 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >33 publications with SOCS3 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >480 publications with SOCS3 and Blood
 Liver Antibodies  >217 publications with SOCS3 and Liver
 Brain Antibodies  >185 publications with SOCS3 and Brain
 Bone Antibodies  >87 publications with SOCS3 and Bone
 Adipose Tissue Antibodies  >83 publications with SOCS3 and Adipose Tissue
 Lung Antibodies  >73 publications with SOCS3 and Lung
 Vascular Antibodies  >69 publications with SOCS3 and Vascular
 Heart Antibodies  >66 publications with SOCS3 and Heart
 Connective Tissue Antibodies  >61 publications with SOCS3 and Connective Tissue
 Kidney Antibodies  >52 publications with SOCS3 and Kidney
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