NP_001092195.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,460 Da
NCBI Official Full Name
T-cell leukemia/lymphoma protein 1A
NCBI Official Synonym Full Names
T-cell leukemia/lymphoma 1A
NCBI Official Synonym Symbols
NCBI Protein Information
T-cell leukemia/lymphoma protein 1A
UniProt Protein Name
T-cell leukemia/lymphoma protein 1A
UniProt Synonym Protein Names
Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1
UniProt Synonym Gene Names
NCBI Summary for TCL1A
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
UniProt Comments for TCL1A
TCL1A: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. Belongs to the TCL1 family.
Protein type: Oncoprotein; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 14q32.13
Molecular Function: identical protein binding; protein binding
Biological Process: multicellular organismal development
Research Articles on TCL1A
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Products associated with TCL1A elisa kit
Pathways associated with TCL1A elisa kit
Diseases associated with TCL1A elisa kit
Organs/Tissues associated with TCL1A elisa kit
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