NP_001019887.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
223,892 Da
NCBI Official Full Name
TRIO and F-actin-binding protein isoform 1
NCBI Official Synonym Full Names
TRIO and F-actin binding protein
NCBI Official Synonym Symbols
Tara; AI428493; EST478828; mKIAA1662 [Similar Products]
NCBI Protein Information
TRIO and F-actin-binding protein
UniProt Protein Name
TRIO and F-actin-binding protein
UniProt Synonym Protein Names
Protein Tara; Trio-associated repeat on actin
UniProt Synonym Gene Names
UniProt Entry Name
TARA_MOUSE
NCBI Summary for TRIOBP
This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]
UniProt Comments for TRIOBP
Tara: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Defects in TRIOBP are the cause of deafness autosomal recessive type 28 (DFNB28). 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Actin-binding; Cytoskeletal
Cellular Component: actin cytoskeleton; cytoplasm; cytoskeleton; focal adhesion; nucleus
Molecular Function: actin binding; actin filament binding; ubiquitin protein ligase binding
Biological Process: cell cycle; cell division; mitosis; regulation of actin cytoskeleton organization and biogenesis
Research Articles on TRIOBP
Precautions
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Diseases associated with TRIOBP elisa kit
Organs/Tissues associated with TRIOBP elisa kit
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