NP_001035196.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,415 Da
NCBI Official Full Name
voltage-gated hydrogen channel 1 isoform 1
NCBI Official Synonym Full Names
hydrogen voltage-gated channel 1
NCBI Official Synonym Symbols
NCBI Protein Information
voltage-gated hydrogen channel 1; voltage sensor domain-only protein
UniProt Protein Name
Voltage-gated hydrogen channel 1
UniProt Synonym Protein Names
Hydrogen voltage-gated channel 1; HV1; Voltage sensor domain-only protein
UniProt Synonym Gene Names
UniProt Entry Name
HVCN1_HUMAN
NCBI Summary for HVCN1
This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for HVCN1
HVCN1: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. Belongs to the hydrogen channel family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane
Molecular Function: voltage-gated cation channel activity; voltage-gated proton channel activity
Biological Process: sperm-egg recognition; proton transport; response to zinc ion; single fertilization; multicellular organism reproduction; response to pH
Research Articles on HVCN1
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Products associated with HVCN1 elisa kit
Pathways associated with HVCN1 elisa kit
Diseases associated with HVCN1 elisa kit
Organs/Tissues associated with HVCN1 elisa kit
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