NP_059830.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,694 Da
NCBI Official Full Name
WD repeat-containing protein 1 isoform 1
NCBI Official Synonym Full Names
WD repeat domain 1
NCBI Protein Information
WD repeat-containing protein 1; actin-interacting protein 1; epididymis secretory protein Li 52
UniProt Protein Name
WD repeat-containing protein 1
UniProt Synonym Protein Names
Actin-interacting protein 1; AIP1; NORI-1
UniProt Synonym Gene Names
UniProt Entry Name
WDR1_HUMAN
NCBI Summary for WDR1
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for WDR1
WDR1: a WD40 repeat cytoskeletal protein that induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Three alternatively spliced human isoforms have been described.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 4p16.1
Cellular Component: cell projection; cytoplasm; extracellular region; actin filament; podosome; cell junction; cytosol
Molecular Function: actin binding
Biological Process: platelet activation; platelet degranulation; sensory perception of sound; regulation of oligodendrocyte differentiation; blood coagulation
Research Articles on WDR1
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Products associated with WDR1 elisa kit
Pathways associated with WDR1 elisa kit
Diseases associated with WDR1 elisa kit
Organs/Tissues associated with WDR1 elisa kit
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