AAH24214.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
104,997 Da
NCBI Official Full Name
ADAM19 protein, partial
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 19
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 19; ADAM 19; meltrin-beta; metalloprotease-disintegrin meltrin beta; metalloprotease and disintegrin dendritic antigen marker; a disintegrin and metalloproteinase domain 19 (meltrin beta)
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 19
UniProt Synonym Protein Names
Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker
UniProt Synonym Gene Names
UniProt Entry Name
ADA19_HUMAN
NCBI Summary for ADAM19
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]
UniProt Comments for ADAM19
ADAM19: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; EC 3.4.24.-; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 5q33.3
Cellular Component: integral to membrane
Molecular Function: zinc ion binding; metalloendopeptidase activity; SH3 domain binding
Biological Process: heart development; membrane protein ectodomain proteolysis
Research Articles on ADAM19
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Products associated with ADAM19 elisa kit
Diseases associated with ADAM19 elisa kit
Organs/Tissues associated with ADAM19 elisa kit
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