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ADAM8 elisa kit :: Cat A Disintegrin and Metalloprotease 8 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS054963 ADAM8 elisa kit
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin and Metalloprotease 8 (ADAM8), ELISA Kit

 Also Known As   

Cat A Disintegrin and Metalloprotease 8 ELISA Kit

 Product Gene Name   

ADAM8 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 10; NC_000010.10 (135075920..135090407, complement). Location: 10q26.3
 OMIM    602267
 3D Structure    ModBase 3D Structure for P78325
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 Species Reactivity    Cat
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ADAM8 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ADAM8 purchase    MBS054963 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 8 (ADAM8) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ADAM8. The ELISA analytical biochemical technique of the MBS054963 kit is based on ADAM8 antibody-ADAM8 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAM8 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAM8. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ADAM8. It may not necessarily be applicable to this product.
 NCBI GI #    109731932
 NCBI GeneID    101
 NCBI Accession #    AAI15405.1 [Other Products]
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 UniProt Primary Accession #    P78325 [Other Products]
 UniProt Secondary Accession #    B4DVM6; H0YL36; H0YLR0; H0YN39 [Other Products]
 UniProt Related Accession #    P78325 [Other Products]
 Molecular Weight    88,771 Da
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 NCBI Official Full Name    ADAM8 protein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 8
 NCBI Official Symbol    ADAM8 [Similar Products]
 NCBI Official Synonym Symbols   
MS2; CD156
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 8; cell surface antigen MS2; human leukocyte differentiation antigen; a disintegrin and metalloproteinase domain 8
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 8
 UniProt Synonym Protein Names   
Cell surface antigen MS2
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAM8 [Similar Products]
 UniProt Synonym Gene Names    MS2; ADAM 8 [Similar Products]
 UniProt Entry Name    ADAM8_HUMAN
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 NCBI Summary for ADAM8    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
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 UniProt Comments for ADAM8    ADAM8: Possible involvement in extravasation of leukocytes.

Protein type: Protease; Membrane protein, integral; EC 3.4.24.-; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: specific granule; cell surface; integral to plasma membrane; cytoplasm; plasma membrane; podosome; dense core granule membrane

Molecular Function: protein binding; protein self-association; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; calcium ion binding; cell adhesion molecule binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of cell adhesion; cell morphogenesis; proteolysis; positive regulation of membrane protein ectodomain proteolysis; leukocyte migration during inflammatory response; activation of NF-kappaB transcription factor; positive regulation of T cell differentiation in the thymus; extracellular matrix disassembly; positive regulation of protein kinase B signaling cascade; cell-cell adhesion; regulation of cell-cell adhesion; positive regulation of protein secretion; positive regulation of acute inflammatory response; positive regulation of bone resorption; negative regulation of neuron apoptosis; angiogenesis; inflammatory response; lymphocyte chemotaxis
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 Research Articles on ADAM8    1. These findings suggest for the first time that ADAM8 is frequently overexpressed in human gliomas and is closely associated with poor clinical outcome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with ADAM8 elisa kitOrgans/Tissues associated with ADAM8 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >34 publications with ADAM8 and Inflammation
 Neoplasms Antibodies  >26 publications with ADAM8 and Neoplasms
 Necrosis Antibodies  >17 publications with ADAM8 and Necrosis
 Disease Models, Animal Antibodies  >9 publications with ADAM8 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >7 publications with ADAM8 and Cardiovascular Diseases
 Carcinoma, Squamous Cell Antibodies  >6 publications with ADAM8 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >5 publications with ADAM8 and Lung Neoplasms
 Drug Toxicity Antibodies  >4 publications with ADAM8 and Drug Toxicity
 Pneumonia Antibodies  >4 publications with ADAM8 and Pneumonia
 Neoplasms, Experimental Antibodies  >4 publications with ADAM8 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >37 publications with ADAM8 and Blood
 Lung Antibodies  >21 publications with ADAM8 and Lung
 Brain Antibodies  >13 publications with ADAM8 and Brain
 Bone Marrow Antibodies  >6 publications with ADAM8 and Bone Marrow
 Connective Tissue Antibodies  >6 publications with ADAM8 and Connective Tissue
 Kidney Antibodies  >5 publications with ADAM8 and Kidney
 Stomach Antibodies  >4 publications with ADAM8 and Stomach
 Spleen Antibodies  >2 publications with ADAM8 and Spleen
 Prostate Antibodies  >2 publications with ADAM8 and Prostate
 Lymph Node Antibodies  >2 publications with ADAM8 and Lymph Node
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