NP_001709.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,226 Da
NCBI Official Full Name
bone morphogenetic protein 6 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 6
NCBI Official Synonym Symbols
NCBI Protein Information
bone morphogenetic protein 6; BMP-6; VGR-1; VG-1-R; VG-1-related protein; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related)
UniProt Protein Name
Bone morphogenetic protein 6
UniProt Synonym Protein Names
VG-1-related protein
UniProt Synonym Gene Names
UniProt Entry Name
BMP6_HUMAN
NCBI Summary for BMP6
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]
UniProt Comments for BMP6
BMP6: Induces cartilage and bone formation. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 6p24-p23
Cellular Component: extracellular space; cytoplasm
Molecular Function: growth factor activity; protein heterodimerization activity; cytokine activity; transforming growth factor beta receptor binding
Biological Process: cellular iron ion homeostasis; response to glucocorticoid stimulus; regulation of apoptosis; BMP signaling pathway; response to magnesium ion; positive regulation of endothelial cell differentiation; positive regulation of aldosterone biosynthetic process; male genitalia development; inflammatory response; kidney development; response to iron ion; skeletal development; endochondral ossification; response to retinoic acid; positive regulation of bone mineralization; osteoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of chondrocyte differentiation; eye development; positive regulation of protein secretion; cartilage development; regulation of MAPKKK cascade; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of endothelial cell proliferation; response to activity; positive regulation of neuron differentiation; positive regulation of epithelial cell proliferation; growth
Research Articles on BMP6
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Products associated with BMP6 elisa kit
Pathways associated with BMP6 elisa kit
Diseases associated with BMP6 elisa kit
Organs/Tissues associated with BMP6 elisa kit
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