NP_001276868.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,572 Da
NCBI Official Full Name
excitatory amino acid transporter 1 isoform 4
NCBI Official Synonym Full Names
solute carrier family 1 (glial high affinity glutamate transporter), member 3
NCBI Protein Information
excitatory amino acid transporter 1; GLAST-1; solute carrier family 1 member 3; sodium-dependent glutamate/aspartate transporter 1
UniProt Protein Name
Excitatory amino acid transporter 1
UniProt Synonym Protein Names
Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3
UniProt Synonym Gene Names
UniProt Entry Name
EAA1_HUMAN
NCBI Summary for EAAT1
This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]
UniProt Comments for EAAT1
SLC1A3: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Mitochondrial; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5p13
Cellular Component: cell projection; cell surface; membrane; cell soma; plasma membrane; integral to membrane; fibril
Molecular Function: glutamate binding; high-affinity glutamate transmembrane transporter activity; sodium:dicarboxylate symporter activity; L-glutamate transmembrane transporter activity
Biological Process: response to drug; response to light stimulus; cranial nerve development; auditory behavior; glutamate biosynthetic process; positive regulation of synaptic transmission; response to antibiotic; synaptic transmission; L-glutamate import; sensory perception of sound; neuron morphogenesis during differentiation; gamma-aminobutyric acid biosynthetic process; response to wounding; neurotransmitter uptake; ion transport; neuromuscular process controlling balance; transmembrane transport
Disease: Episodic Ataxia, Type 6
Research Articles on EAAT1
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Products associated with EAAT1 elisa kit
Pathways associated with EAAT1 elisa kit
Diseases associated with EAAT1 elisa kit
Organs/Tissues associated with EAAT1 elisa kit
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