NP_005600.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
97,092 Da
NCBI Official Full Name
glycogen phosphorylase, muscle form isoform 1
NCBI Official Synonym Full Names
phosphorylase, glycogen, muscle
NCBI Protein Information
glycogen phosphorylase, muscle form; myophosphorylase
UniProt Protein Name
Glycogen phosphorylase, muscle form
UniProt Synonym Protein Names
Myophosphorylase
UniProt Entry Name
PYGM_HUMAN
NCBI Summary for PYGM
This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]
UniProt Comments for PYGM
PYGM: an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Dimers associate into a tetramer to form the enzymatically active phosphorylase A. Phosphorylation of Ser-14 converts phosphorylase B (unphosphorylated) to phosphorylase A.
Protein type: Phosphorylase; Endoplasmic reticulum; EC 2.4.1.1; Transferase; Carbohydrate Metabolism - starch and sucrose
Chromosomal Location of Human Ortholog: 11q12-q13.2
Cellular Component: cytosol
Molecular Function: glycogen phosphorylase activity; nucleotide binding; pyridoxal phosphate binding
Biological Process: glycogen metabolic process; glycogen catabolic process; carbohydrate metabolic process; glucose metabolic process; pathogenesis
Disease: Glycogen Storage Disease V
Research Articles on PYGM
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Products associated with PYGM elisa kit
Pathways associated with PYGM elisa kit
Diseases associated with PYGM elisa kit
Organs/Tissues associated with PYGM elisa kit
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