CAG33229.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
Molecular Weight
26,671 Da
NCBI Official Full Name
PROCR
UniProt Protein Name
Endothelial protein C receptor
UniProt Synonym Protein Names
Activated protein C receptor; APC receptor; Endothelial cell protein C receptor
UniProt Synonym Gene Names
UniProt Entry Name
EPCR_HUMAN
NCBI Summary for PROCR
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
UniProt Comments for PROCR
EPCR: a single-pass type I membrane protein. Binds activated protein C (APC), a serine protease that regulates thrombin (IIa) production. Plays a pivotal role in preventing blood coagulation through binding of activated protein C. Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. The binding of APC to EPCR and PAR-1 increases invasion and chemotaxis.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 20q11.2
Cellular Component: centrosome; cell surface; focal adhesion; integral to plasma membrane; extracellular region; plasma membrane
Molecular Function: protein binding; receptor activity
Biological Process: antigen processing and presentation; immune response; negative regulation of coagulation; blood coagulation; leukocyte migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with PROCR elisa kit
Diseases associated with PROCR elisa kit
Organs/Tissues associated with PROCR elisa kit
|