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ACVR2A elisa kit :: Cavy Activin A Receptor Type II A ELISA Kit

Scan QR to view Datasheet Catalog #    MBS060994 ACVR2A elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activin A Receptor Type II A (ACVR2A), ELISA Kit

 Also Known As   

Cavy Activin A Receptor Type II A ELISA Kit

 Product Gene Name   

ACVR2A elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    102581
 3D Structure    ModBase 3D Structure for P27037
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 Species Reactivity    Cavy
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of ACVR2A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ACVR2A purchase    MBS060994 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Activin A Receptor Type II A (ACVR2A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACVR2A. The ELISA analytical biochemical technique of the MBS060994 kit is based on ACVR2A antibody-ACVR2A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACVR2A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACVR2A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ACVR2A. It may not necessarily be applicable to this product.
 NCBI GI #    178050
 NCBI GeneID    92
 NCBI Accession #    AAA35504.1 [Other Products]
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 UniProt Primary Accession #    P27037 [Other Products]
 UniProt Secondary Accession #    Q53TH4; Q6NWV2; Q92474; B2RAB8; B4DWQ2; D3DP85 [Other Products]
 UniProt Related Accession #    P27037 [Other Products]
 Molecular Weight    57,848 Da
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 NCBI Official Full Name    activin type II receptor
 NCBI Official Synonym Full Names    activin A receptor, type IIA
 NCBI Official Symbol    ACVR2A [Similar Products]
 NCBI Official Synonym Symbols   
ACVR2; ACTRII
[Similar Products]
 NCBI Protein Information    activin receptor type-2A
 UniProt Protein Name    Activin receptor type-2A
 UniProt Synonym Protein Names   
Activin receptor type IIA
 Protein Family    Activin receptor
 UniProt Gene Name    ACVR2A [Similar Products]
 UniProt Synonym Gene Names    ACVR2; ACTR-IIA; ACTRIIA [Similar Products]
 UniProt Entry Name    AVR2A_HUMAN
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 NCBI Summary for ACVR2A    This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
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 UniProt Comments for ACVR2A    ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.

Protein type: Kinase, protein; Motility/polarity/chemotaxis; EC 2.7.11.30; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 2q22.3

Cellular Component: cell surface; integral to plasma membrane; cytoplasm; plasma membrane; receptor complex

Molecular Function: activin receptor activity; protein self-association; metal ion binding; transmembrane receptor protein serine/threonine kinase activity; PDZ domain binding; transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; growth factor binding; activin binding; coreceptor activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: embryonic skeletal development; positive regulation of erythrocyte differentiation; regulation of BMP signaling pathway; activin receptor signaling pathway; Sertoli cell proliferation; gastrulation with mouth forming second; positive regulation of bone mineralization; protein amino acid phosphorylation; anterior/posterior pattern formation; BMP signaling pathway; positive regulation of osteoblast differentiation; positive regulation of activin receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; mesoderm development; spermatogenesis; positive regulation of protein amino acid phosphorylation; sperm ejaculation; regulation of nitric-oxide synthase activity; determination of left/right symmetry; penile erection
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 Research Articles on ACVR2A    1. For ACVR2A SNPs (rs10497025, rs1128919, rs13430086), no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACVR2A elisa kitPathways associated with ACVR2A elisa kit
 Reference Product  PubMed Publications
 BMP2 elisa kit  >6 publications with ACVR2A and BMP2
 BMP7 elisa kit  >6 publications with ACVR2A and BMP7
 SMAD4 elisa kit  >1 publications with ACVR2A and SMAD4
 INHA elisa kit  >1 publications with ACVR2A and INHA
 INHBB elisa kit  >1 publications with ACVR2A and INHBB
 ACVRL1 elisa kit  >1 publications with ACVR2A and ACVRL1
 ACVR1B elisa kit  >1 publications with ACVR2A and ACVR1B
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with ACVR2A elisa kitOrgans/Tissues associated with ACVR2A elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with ACVR2A and Neoplasms
 Congenital Abnormalities Antibodies  >3 publications with ACVR2A and Congenital Abnormalities
 Cardiovascular Diseases Antibodies  >3 publications with ACVR2A and Cardiovascular Diseases
 Craniofacial Abnormalities Antibodies  >2 publications with ACVR2A and Craniofacial Abnormalities
 Nervous System Diseases Antibodies  >2 publications with ACVR2A and Nervous System Diseases
 Disease Models, Animal Antibodies  >2 publications with ACVR2A and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with ACVR2A and Breast Neoplasms
 Hypertrophy Antibodies  >1 publications with ACVR2A and Hypertrophy
 Heart Defects, Congenital Antibodies  >1 publications with ACVR2A and Heart Defects, Congenital
 Fibrosis Antibodies  >1 publications with ACVR2A and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with ACVR2A and Blood
 Placenta Antibodies  >5 publications with ACVR2A and Placenta
 Embryonic Tissue Antibodies  >3 publications with ACVR2A and Embryonic Tissue
 Ovary Antibodies  >3 publications with ACVR2A and Ovary
 Pancreas Antibodies  >2 publications with ACVR2A and Pancreas
 Muscle Antibodies  >2 publications with ACVR2A and Muscle
 Liver Antibodies  >1 publications with ACVR2A and Liver
 Mammary Gland Antibodies  >1 publications with ACVR2A and Mammary Gland
 Testis Antibodies  >1 publications with ACVR2A and Testis
 Eye Antibodies  >1 publications with ACVR2A and Eye
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