AAQ91330.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,635 Da
NCBI Official Full Name
cysteinyl leukotriene receptor 2
NCBI Official Synonym Full Names
cysteinyl leukotriene receptor 2
NCBI Official Synonym Symbols
HG57; CYSLT2; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146 [Similar Products]
NCBI Protein Information
cysteinyl leukotriene receptor 2; G protein-coupled receptor; G-protein coupled receptor HG57; G-protein coupled receptor GPCR21; cysteinyl leukotriene CysLT2 receptor
UniProt Protein Name
Cysteinyl leukotriene receptor 2
UniProt Synonym Protein Names
G-protein coupled receptor GPCR21; hGPCR21; G-protein coupled receptor HG57; HPN321
UniProt Synonym Gene Names
UniProt Entry Name
CLTR2_HUMAN
NCBI Summary for CYSLTR2
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
UniProt Comments for CYSLTR2
CYSLTR2: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR
Chromosomal Location of Human Ortholog: 13q14.2
Cellular Component: plasma membrane; integral to membrane
Molecular Function: protein binding; cysteinyl leukotriene receptor activity; leukotriene receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; immune response
Research Articles on CYSLTR2
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Products associated with CYSLTR2 elisa kit
Pathways associated with CYSLTR2 elisa kit
Diseases associated with CYSLTR2 elisa kit
Organs/Tissues associated with CYSLTR2 elisa kit
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