NP_005373.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,472 Da
NCBI Official Full Name
neurofilament medium polypeptide isoform 1
NCBI Official Synonym Full Names
neurofilament, medium polypeptide
NCBI Protein Information
neurofilament medium polypeptide; neurofilament 3; 160 kDa neurofilament protein; neurofilament triplet M protein; neurofilament-3 (150 kD medium); neurofilament, medium polypeptide 150kDa
UniProt Protein Name
Neurofilament medium polypeptide
UniProt Synonym Protein Names
160 kDa neurofilament protein; Neurofilament 3; Neurofilament triplet M protein
UniProt Synonym Gene Names
UniProt Entry Name
NFM_HUMAN
NCBI Summary for NEF3
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
UniProt Comments for NEF3
NFM: a neurofilament intermediate filament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The levels of phosphorylation are altered developmentally and coincident with a change in the neurofilament function.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 8p21
Cellular Component: axon; neurofilament; neuromuscular junction
Molecular Function: protein binding; structural constituent of cytoskeleton; microtubule binding
Biological Process: neurofilament bundle assembly; axon cargo transport; regulation of axon diameter; microtubule cytoskeleton organization and biogenesis
Research Articles on NEF3
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Products associated with NEF3 elisa kit
Pathways associated with NEF3 elisa kit
Diseases associated with NEF3 elisa kit
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