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SIL-6R elisa kit :: Cavy Soluble Interleukin 6 Receptor ELISA Kit

Scan QR to view Datasheet Catalog #    MBS027236 SIL-6R elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Soluble Interleukin 6 Receptor (SIL-6R), ELISA Kit

 Also Known As   

Cavy Soluble Interleukin 6 Receptor ELISA Kit

 Product Gene Name   

SIL-6R elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (154377669..154441926). Location: 1q21
 OMIM    147880
 3D Structure    ModBase 3D Structure for P08887
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 Species Reactivity    Cavy
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SIL-6R elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SIL-6R purchase    MBS027236 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Soluble Interleukin 6 Receptor (SIL-6R) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SIL-6R. The ELISA analytical biochemical technique of the MBS027236 kit is based on SIL-6R antibody-SIL-6R antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SIL-6R antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SIL-6R. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SIL-6R. It may not necessarily be applicable to this product.
 NCBI GI #    633863
 NCBI GeneID    3570
 NCBI Accession #    AAC60635.1 [Other Products]
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 UniProt Primary Accession #    P08887 [Other Products]
 UniProt Secondary Accession #    Q16202; Q53EQ7; Q5FWG2; Q5VZ23; A8KAE8; B2R6V4 [Other Products]
 UniProt Related Accession #    P08887 [Other Products]
 Molecular Weight    51,548 Da
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 NCBI Official Full Name    Soluble interleukin-6 receptor
 NCBI Official Synonym Full Names    interleukin 6 receptor
 NCBI Official Symbol    IL6R [Similar Products]
 NCBI Official Synonym Symbols   
IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1
[Similar Products]
 NCBI Protein Information    interleukin-6 receptor subunit alpha; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha
 UniProt Protein Name    Interleukin-6 receptor subunit alpha
 UniProt Synonym Protein Names   
IL-6R 1; Membrane glycoprotein 80
 UniProt Gene Name    IL6R [Similar Products]
 UniProt Synonym Gene Names    IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; gp80 [Similar Products]
 UniProt Entry Name    IL6RA_HUMAN
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 NCBI Summary for SIL-6R    This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
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 UniProt Comments for SIL-6R    IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular space; basolateral plasma membrane; apical plasma membrane; extracellular region; plasma membrane; interleukin-6 receptor complex

Molecular Function: protein binding; interleukin-6 receptor binding; enzyme binding; interleukin-6 binding; protein homodimerization activity; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity

Biological Process: negative regulation of collagen biosynthetic process; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; neutrophil mediated immunity; positive regulation of interleukin-6 production; positive regulation of leukocyte chemotaxis; defense response to Gram-negative bacterium; endocrine pancreas development; positive regulation of chemokine production; activation of NF-kappaB transcription factor; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; monocyte chemotaxis; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; response to cytokine stimulus; positive regulation of cell proliferation; acute-phase response; negative regulation of interleukin-8 production; hepatic immune response

Disease: Interleukin 6, Serum Level Of, Quantitative Trait Locus; Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus
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 Research Articles on SIL-6R    1. The IL-6R 48892 A/C polymorphism is associated with high TG and WC, and low HDL-C levels in adolescents
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SIL-6R elisa kitPathways associated with SIL-6R elisa kit
 Reference Product  PubMed Publications
 IL6 elisa kit  >87 publications with SIL-6R and IL6
 STAT3 elisa kit  >20 publications with SIL-6R and STAT3
 IL6ST elisa kit  >15 publications with SIL-6R and IL6ST
 STAT1 elisa kit  >3 publications with SIL-6R and STAT1
 JAK2 elisa kit  >3 publications with SIL-6R and JAK2
 SOCS3 elisa kit  >2 publications with SIL-6R and SOCS3
 JAK1 elisa kit  >2 publications with SIL-6R and JAK1
 CNTF elisa kit  >1 publications with SIL-6R and CNTF
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-6 Signaling Pathway antibodies  Interleukin-6 Signaling Pathway Diagram
Diseases associated with SIL-6R elisa kitOrgans/Tissues associated with SIL-6R elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >56 publications with SIL-6R and Inflammation
 Neoplasms Antibodies  >35 publications with SIL-6R and Neoplasms
 Immune System Diseases Antibodies  >34 publications with SIL-6R and Immune System Diseases
 Cardiovascular Diseases Antibodies  >32 publications with SIL-6R and Cardiovascular Diseases
 Arthritis, Rheumatoid Antibodies  >20 publications with SIL-6R and Arthritis, Rheumatoid
 Heart Diseases Antibodies  >19 publications with SIL-6R and Heart Diseases
 Necrosis Antibodies  >18 publications with SIL-6R and Necrosis
 Nervous System Diseases Antibodies  >10 publications with SIL-6R and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >8 publications with SIL-6R and Carcinoma, Hepatocellular
 Hematologic Diseases Antibodies  >8 publications with SIL-6R and Hematologic Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >77 publications with SIL-6R and Blood
 Heart Antibodies  >23 publications with SIL-6R and Heart
 Vascular Antibodies  >17 publications with SIL-6R and Vascular
 Liver Antibodies  >11 publications with SIL-6R and Liver
 Kidney Antibodies  >10 publications with SIL-6R and Kidney
 Bone Antibodies  >10 publications with SIL-6R and Bone
 Lung Antibodies  >10 publications with SIL-6R and Lung
 Muscle Antibodies  >8 publications with SIL-6R and Muscle
 Brain Antibodies  >7 publications with SIL-6R and Brain
 Bone Marrow Antibodies  >3 publications with SIL-6R and Bone Marrow
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