NP_059121.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,406 Da
NCBI Official Full Name
sperm surface protein Sp17
NCBI Official Synonym Full Names
sperm autoantigenic protein 17
NCBI Protein Information
sperm surface protein Sp17; sperm protein 17; cancer/testis antigen 22
UniProt Protein Name
Sperm surface protein Sp17
UniProt Synonym Protein Names
Cancer/testis antigen 22; CT22; Sp17-1; Sperm autoantigenic protein 17
UniProt Synonym Gene Names
UniProt Entry Name
SP17_HUMAN
NCBI Summary for SP17
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]
UniProt Comments for SP17
SPA17: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.
Protein type: Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 11q24.2
Cellular Component: membrane; cytoplasm
Molecular Function: calmodulin binding
Biological Process: binding of sperm to zona pellucida; single fertilization; spermatogenesis
Research Articles on SP17
Precautions
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Products associated with SP17 elisa kit
Diseases associated with SP17 elisa kit
Organs/Tissues associated with SP17 elisa kit
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