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TPOR elisa kit :: Cavy Thrombopoietin Receptor Antibody ELISA Kit

Scan QR to view Datasheet Catalog #    MBS022846 TPOR elisa kit
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 Product Name   

Thrombopoietin Receptor Antibody (TPOR), ELISA Kit

 Also Known As   

Cavy Thrombopoietin Receptor Antibody ELISA Kit

 Product Gene Name   

TPOR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    187950
 3D Structure    ModBase 3D Structure for P40225
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 Species Reactivity    Cavy
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TPOR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TPOR purchase    MBS022846 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Thrombopoietin Receptor Antibody (TPOR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TPOR. The ELISA analytical biochemical technique of the MBS022846 kit is based on TPOR antibody-TPOR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TPOR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TPOR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for TPOR. It may not necessarily be applicable to this product.
 NCBI GI #    730982
 NCBI GeneID    7066
 NCBI Accession #    P40225.1 [Other Products]
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 UniProt Primary Accession #    P40225 [Other Products]
 UniProt Secondary Accession #    Q13020; Q15790; Q15791; Q15792; A1L3Y0; B7ZLR8; B9EGA8 [Other Products]
 UniProt Related Accession #    P40225 [Other Products]
 Molecular Weight    37,823 Da
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 NCBI Official Full Name    Thrombopoietin
 NCBI Official Synonym Full Names    thrombopoietin
 NCBI Official Symbol    THPO [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    thrombopoietin; MPL ligand; c-mpl ligand; prepro-thrombopoietin; megakaryocyte stimulating factor; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; myeloproliferative leukemia virus oncogene ligand
 UniProt Protein Name    Thrombopoietin
 UniProt Synonym Protein Names   
C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand
 UniProt Gene Name    THPO [Similar Products]
 UniProt Synonym Gene Names    MGDF; ML; MGDF [Similar Products]
 UniProt Entry Name    TPO_HUMAN
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 NCBI Summary for TPOR    Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
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 UniProt Comments for TPOR    THPO: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular space

Molecular Function: growth factor activity; hormone activity; cytokine activity

Biological Process: cell proliferation; platelet activation; positive regulation of protein kinase B signaling cascade; multicellular organismal development; positive regulation of megakaryocyte differentiation; myeloid cell differentiation; positive regulation of protein amino acid phosphorylation; blood coagulation

Disease: Thrombocythemia 1
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 Research Articles on TPOR    1. An Arg->Cys substitution at residue 38 or residue 17 excluding the 21-AA signal peptide of the receptor binding domain was found in a family with aplastic anemia. Adding a 5th cysteine may disrupt normal disulfide bonding & receptor binding.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TPOR elisa kitPathways associated with TPOR elisa kit
 Reference Product  PubMed Publications
 MPL elisa kit  >22 publications with TPOR and MPL
 KITLG elisa kit  >8 publications with TPOR and KITLG
 SELP elisa kit  >1 publications with TPOR and SELP
 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Aggregation (Plug Formation) Pathway antibodies  Platelet Aggregation (Plug Formation) Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
Diseases associated with TPOR elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with TPOR and Neoplasms
 Thrombocytosis Antibodies  >8 publications with TPOR and Thrombocytosis
 Anemia Antibodies  >5 publications with TPOR and Anemia
 Lung Neoplasms Antibodies  >3 publications with TPOR and Lung Neoplasms
 Congenital Abnormalities Antibodies  >2 publications with TPOR and Congenital Abnormalities
 Carcinoma, Squamous Cell Antibodies  >2 publications with TPOR and Carcinoma, Squamous Cell
 Disease Models, Animal Antibodies  >2 publications with TPOR and Disease Models, Animal
 Thrombocythemia, Essential Antibodies  >2 publications with TPOR and Thrombocythemia, Essential
 Pain Antibodies  >2 publications with TPOR and Pain
 Hypertension Antibodies  >1 publications with TPOR and Hypertension
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